Publications

Journal Article (15)

2018
Journal Article
Acevedo-Rocha, C. G.; Sun, Z.; Reetz, M. T. Clarifying the Difference between Iterative Saturation Mutagenesis as a Rational Guide in Directed Evolution and OmniChange as a Gene Mutagenesis Technique. Chembiochem 2018, 19, 2542–2544.
Journal Article
Cadet, F.; Fontaine, N.; Li, G.; Sanchis, J.; Chong, M. N. F.; Pandjaitan, R.; Vetrivel, I.; Offmann, B.; Reetz, M. T. A Machine Learning Approach for Reliable Prediction of Amino Acid Interactions and its Application in the Directed Evolution of Enantioselective Enzymes. Scientific Reports 2018, 8.
Journal Article
Li, A.; Sun, Z.; Reetz, M. T. Solid‐Phase Gene Synthesis for Mutant Library Construction: The Future of Directed Evolution? Chembiochem 2018, 19, 2023–2032.
Journal Article
She, W.; Ni, J.; Shui, K.; Wang, F.; He, R.; Xue, J.; Reetz, M. T.; Li, A.; Ma, L. Rapid and Error-Free Site-Directed Mutagenesis by a PCR-Free In Vitro CRISPR/Cas9-Mediated Mutagenic System. ACS Synthetic Biology 2018, 7, 2236–2244.
Journal Article
Li, G.; Garcia-Borràs, M.; Fürst, M. J. L. J.; Ilie, A.; Fraaije, M. W.; Houk, K. N.; Reetz, M. T. Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution. Journal of the American Chemical Society 2018, 140, 10464–10472.
Journal Article
Ilie, A.; Harms, K.; Reetz, M. T. P450-Catalyzed Regio- and Stereoselective Oxidative Hydroxylation of 6-Iodotetralone: Preparative-Scale Synthesis of a Key Intermediate for Pd-Catalyzed Transformations. The Journal of Organic Chemistry 2018, 83, 7504–7508.
Journal Article
König, G.; Reetz, M. T.; Thiel, W. 1-Butanol as a Solvent for Efficient Extraction of Polar Compounds from Aqueous Medium: Theoretical and Practical Aspects. The Journal of Physical Chemistry B 2018, 122, 6975–6988.
Journal Article
Schrimpf, A.; Hempel, F.; Li, A.; Linne, U.; Maier, U. G.; Reetz, M. T.; Geyer, A. Hinge-Type Dimerization of Proteins by a Tetracysteine Peptide of High Pairing Specificity. Biochemistry 2018, 57, 3658–3664.
Journal Article
Li, A.; Acevedo-Rocha, C. G.; Reetz, M. T. Boosting the Efficiency of Site-Saturation Mutagenesis for a Difficult-to-Randomize Gene by a Two-Step PCR Strategy. Applied Microbiology and Biotechnology 2018, 102, 6095–6103.
Journal Article
Acevedo-Rocha, C. G.; Gamble, C. G.; Lonsdale, R.; Li, A.; Nett, N.; Hoebenreich, S.; Lingnau, J. B.; Wirtz, C.; Fares, C.; Hinrichs, H.; Deege, A.; Mulholland, A. J.; Nov, Y.; Leys, D.; McLean, K. J.; Munro, A. W.; Reetz, M. T. P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping. ACS Catalysis 2018, 8, 3395–3410.
Journal Article
Li, G.; Wang, J.; Reetz, M. T. Biocatalysts for the Pharmaceutical Industry Created by Structure-Guided Directed Evolution of Stereoselective Enzymes. Bioorganic & Medicinal Chemistry 2018, 26, 1241–1251.
Journal Article
Li, A.; Acevedo-Rocha, C. G.; Sun, Z.; Cox, T.; Xu, J. L.; Reetz, M. T. Beating Bias in the Directed Evolution of Proteins: Combining High-Fidelity on-Chip Solid-Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction. Chembiochem 2018, 19, 221–228.
Journal Article
Qu, G.; Lonsdale, R.; Yao, P.; Li, G.; Liu, B.; Reetz, M. T.; Sun, Z. Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis. Chembiochem 2018, 19, 239–246.
Journal Article
Reetz, M. T. Combinatorial Libraries Reloaded[1]. Israel Journal of Chemistry 2018, 58, 52–60.
Journal Article
Sun, Z.; Wu, L.; Bocola, M.; Chan, H. C. S.; Lonsdale, R.; Kong, X.-D.; Yuan, S.; Zhou, J.; Reetz, M. T. Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. Journal of the American Chemical Society 2018, 140, 310–318.

Book Chapter (1)

2018
Book Chapter
Acevedo-Rocha, C. G.; Ferla, M.; Reetz, M. T. Directed Evolution of Proteins Based on Mutational Scanning; Bornscheuer, U. T., Höhne, M., Eds.; Bornscheuer, U. T., Höhne, M., Series Eds.; Methods in Molecular Biology; Springer: New York, 2018; Vol. 1685, pp 87–128.
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