Publications
Journal Article (15)
2018
Journal Article
Reetz, M. T. Clarifying the Difference between Iterative Saturation Mutagenesis as a Rational Guide in Directed Evolution and OmniChange as a Gene Mutagenesis Technique. Chembiochem 2018, 19, 2542–2544.
; ;
Journal Article
Reetz, M. T. A Machine Learning Approach for Reliable Prediction of Amino Acid Interactions and its Application in the Directed Evolution of Enantioselective Enzymes. Scientific Reports 2018, 8, 16757.
; ; ; ; ; ; ; ;
Journal Article
Reetz, M. T. Solid‐Phase Gene Synthesis for Mutant Library Construction: The Future of Directed Evolution? Chembiochem 2018, 19, 2023–2032.
; ;
Journal Article
Reetz, M. T.; ; Rapid and Error-Free Site-Directed Mutagenesis by a PCR-Free In Vitro CRISPR/Cas9-Mediated Mutagenic System. ACS Synthetic Biology 2018, 7, 2236–2244.
; ; ; ; ; ;
Journal Article
Li, G.; ; ; Ilie, A.; ; ; Reetz, M. T. Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution. Journal of the American Chemical Society 2018, 140, 10464–10472.
Journal Article
Ilie, A.; ; Reetz, M. T. P450-Catalyzed Regio- and Stereoselective Oxidative Hydroxylation of 6-Iodotetralone: Preparative-Scale Synthesis of a Key Intermediate for Pd-Catalyzed Transformations. The Journal of Organic Chemistry 2018, 83, 7504–7508.
Journal Article
König, G.; Reetz, M. T.; Thiel, W. 1-Butanol as a Solvent for Efficient Extraction of Polar Compounds from Aqueous Medium: Theoretical and Practical Aspects. The Journal of Physical Chemistry B 2018, 122, 6975–6988.
Journal Article
Li, A.; ; ; Reetz, M. T.; Hinge-Type Dimerization of Proteins by a Tetracysteine Peptide of High Pairing Specificity. Biochemistry 2018, 57, 3658–3664.
; ;
Journal Article
Li, A.; ; Reetz, M. T. Boosting the Efficiency of Site-Saturation Mutagenesis for a Difficult-to-Randomize Gene by a Two-Step PCR Strategy. Applied Microbiology and Biotechnology 2018, 102, 6095–6103.
Journal Article
Acevedo-Rocha, C. G.; ; Lonsdale, R.; Li, A.; ; ; Lingnau, J. B.; Wirtz, C.; Fares, C.; Hinrichs, H.; Deege, A.; ; ; ; ; ; Reetz, M. T. P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping. ACS Catalysis 2018, 8, 3395–3410.
Journal Article
Wang, J.; Reetz, M. T. Biocatalysts for the Pharmaceutical Industry Created by Structure-Guided Directed Evolution of Stereoselective Enzymes. Bioorganic & Medicinal Chemistry 2018, 26, 1241–1251.
;
Journal Article
Li, A.; ; ; ; ; Reetz, M. T. Beating Bias in the Directed Evolution of Proteins: Combining High-Fidelity on-Chip Solid-Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction. Chembiochem 2018, 19, 221–228.
Journal Article
Lonsdale, R.; ; Li, G.; ; Reetz, M. T.; Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis. Chembiochem 2018, 19, 239–246.
;
Journal Article
Reetz, M. T. Combinatorial Libraries Reloaded[1]. Israel Journal of Chemistry 2018, 58, 52–60.
Journal Article
Bocola, M.; ; Lonsdale, R.; ; ; ; Reetz, M. T. Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. Journal of the American Chemical Society 2018, 140, 310–318.
; ; Book Chapter (1)
2018
Book Chapter
Acevedo-Rocha, C. G.; ; Reetz, M. T. Directed Evolution of Proteins Based on Mutational Scanning; , , Eds.; , , Series Eds.; Methods in Molecular Biology; Springer: New York, 2018; Vol. 1685, pp 87–128.