Publications

Journal Article (14)

2016
Journal Article
Luo, X.-J.; Zhao, J.; Li, C.-X.; Bai, Y.-P.; Reetz, M. T.; Yu, H.-L.; Xu, J.-H. Combinatorial Evolution of Phosphotriesterase Toward a Robust Malathion Degrader by Hierarchical Iteration Mutagenesis. Biotechnology and Bioengineering 2016, 113, 2350–2357.
Journal Article
Sun, Z.; Lonsdale, R.; Li, G.; Reetz, M. T. Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- Versus Double-Code Saturation Mutagenesis. Chembiochem 2016, 17, 1865–1872.
Journal Article
Li, A.; Ilie, A.; Sun, Z.; Lonsdale, R.; Xu, J.-H.; Reetz, M. T. Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution. Angewandte Chemie International Edition 2016, 55, 12026–12029.
Journal Article
Sun, Z.; Torres Salas, P.; Siirola, E.; Lonsdale, R.; Reetz, M. T. Exploring Productive Sequence Space in Directed Evolution Using Binary Patterning Versus Conventional Mutagenesis Strategies. Bioresources and Bioprocessing 2016, 3, 1–8.
Journal Article
Sun, Z.; Li, G.; Ilie, A.; Reetz, M. T. Exploring the Substrate Scope of Mutants Derived from the Robust Alcohol Dehydrogenase TbSADH. Tetrahedron Letters 2016, 57, 3648–3651.
Journal Article
Wang, J.; Lonsdale, R.; Reetz, M. T. Exploring Substrate Scope and Stereoselectivity of P450 Peroxygenase OleTJE in Olefin-Forming Oxidative Decarboxylation. Chemical Communications 2016, 52, 8131–8133.
Journal Article
Li, G.; Reetz, M. T. Learning Lessons from Directed Evolution of Stereoselective Enzymes. Organic Chemistry Frontiers 2016, 3, 1350–1358.
Journal Article
Reetz, M. T. What are the Limitations of Enzymes in Synthetic Organic Chemistry? The Chemical Record 2016.
Journal Article
Li, G.; Zhang, H.; Sun, Z.; Liu, X.; Reetz, M. T. Multiparameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity, and Activity of an Epoxide Hydrolase. ACS Catalysis 2016, 6, 3679–3687.
Journal Article
Sun, Z.; Wikmark, Y.; Backvall, J.-E.; Reetz, M. T. New Concepts for Increasing the Efficiency in Directed Evolution of Stereoselective Enzymes. Chemistry – A European Journal 2016, 22, 5046–5054.
Journal Article
Krone, K. M.; Warias, R.; Ritter, C.; Li, A.; Acevedo-Rocha, C. G.; Reetz, M. T.; Belder, D. Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip. Journal of the American Chemical Society 2016, 138, 2102–2105.
Journal Article
Sun, Z.; Lonsdale, R.; Ilie, A.; Li, G.; Zhou, J.; Reetz, M. T. Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple Code Saturation Mutagenesis of an Alcohol Dehydrogenase. ACS Catalysis 2016, 6, 1598–1605.
Journal Article
Sun, Z.; Lonsdale, R.; Li, G.; Li, A.; Wang, J.; Reetz, M. T. Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase. ACS Catalysis 2016, 6, 1590–1597.
Journal Article
Wu, Z.; Reetz, M. T.; Harms, K. Crystal Structure of 7,8,9,10-Tetrahydro-Benzo[b]-Naphtho[2,1-d]Furan. Acta Crystallographica, Section E: Crystal Structure Communications 2016, 72, 106–108.

Book Chapter (1)

2016
Book Chapter
Acevedo-Rocha, C. G.; Reetz, M. T. Handling the Numbers Problem in Directed Evolution. In Understanding Enzymes: Function, Design, Engineering and Analysis; Pan Stanford Publishing Pte. Ltd.: Singapore, 2016; pp 613–642.
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