Homogeneous Catalysis

Our research aims towards the invention of new strategies for the development of “perfect chemical reactions” that combine quantitative yields and high atom economy, while avoiding toxic solvents, protecting group strategies, extreme temperatures, or inert gas atmosphere. We approach this ultimate goal by using selective catalysis based on small organic molecules. In recent years, it has been demonstrated that these organocatalysts can be as efficient and selective as the more commonly used metal-based catalysts, leading to a rapid growth of this field of research all around the globe. As a result of our ongoing investigations, our group was the first to demonstrate the concept of asymmetric counteranion-directed catalysis (ACDC) in 2005. Further investigations target the application of organocatalytic reactions in the synthesis of drugs and natural products.

Research Topics:

Asymmetric Counteranion-Directed Catalysis (ACDC)

Since introducing the concept of asymmetric counteranion-directed catalysis (ACDC) in our studies on asymmetric transfer hydrogenations in 2006, we have continuously striven to apply the method to increasingly challenging chemical transformations. The realisation that any reaction involving a cationic intermediate can potentially... [more]

Carbon Dioxide Splitting and Smart Furan Chemistry

With the visionary support of the Werner Siemens-Stiftung, we are working to master the chemical abstraction of photosynthesis: converting CO₂ into pure carbon and oxygen O₂. Within this framework, we also develop smart new chemistries to convert primary, biobased furans into high-value fine chemicals. [more]

Aminocatalysis

Since our initial studies on the first asymmetric proline-catalysed intermolecular aldol reaction in 2000, we and others have established enamine catalysis as a fundamental concept for the catalytic transformation of carbanion equivalents. These pioneering works laid the foundation for the 2021 Nobel Prize in Chemistry, awarded to Benjamin List and David MacMillan... [more]

Homogeneous Catalysis

Research Topics:

Asymmetric Counteranion-Directed Catalysis (ACDC)

Carbon Dioxide Splitting and Smart Furan Chemistry

Aminocatalysis

A new sustainable raw material for chemistry

Chirality Control: New Ways for Active Ingredients

Minerva’s daughters harness biocatalysis for a sustainable future

Katalyse für die Welt

Verleihung des Gottfried-Wilhelm-Leibnitz-Preises

Research Reports:

Picture Gallery

The List Laboratory