Our research aims towards the invention of new strategies for the development of “perfect chemical reactions” that combine quantitative yields and high atom economy, while avoiding toxic solvents, protecting group strategies, extreme temperatures, or inert gas atmosphere. We approach this ultimate goal by using selective catalysis based on small organic molecules. In recent years, it has been demonstrated that these organocatalysts can be as efficient and selective as the more commonly used metal-based catalysts, leading to a rapid growth of this field of research all around the globe. As a result of our ongoing investigations, our group was the first to demonstrate the concept of asymmetric counteranion-directed catalysis (ACDC) in 2005. Further investigations target the application of organocatalytic reactions in the synthesis of drugs and natural products.
We explore small-molecule amines as asymmetric catalysts for carbonyl transformations. “Asymmetric Aminocatalysis” functions by activating carbonyl compounds as iminium ions and enamines using a catalytic amount of an amine. Our strategy complements....
Due to the vast number of reactions that can be catalyzed by Brønsted acids, a core area of our research focuses on the development and application of chiral organic Brønsted acids for asymmetric counteranion-directed catalysis (ACDC). To date...
To date, the field of Lewis acid catalysis has been dominated by (transition) metal chemistry. To provide purely organic counterparts to these traditional catalytic systems we are dedicated to the synthesis and identification of organic Lewis acids. In 2009, we demonstrated that our chiral disulfonimides (DSI
) are not only excellent Brønsted acids, but form strong Lewis acids upon silylation.
Menthol and cannabinoids are important for the chemical industry. A team led by Prof. Benjamin List has now found a new way to synthesize both substances - cheaper and more efficient than before.
The United Nations have declared the 11th of February as International Day of Women and Girls in Science. We take this as an opportunity to make the women who work at our institute visibile. From now on interviews with female coworkers will be published on a regular basis.
PhD student in the Department of Homogeneous Catalysis receives the 2022 Thiel Award for the best research publication of the past year.
Katalyse für die Welt