Publikationen von Richard Lonsdale

Acevedo-Rocha, C. G.; Gamble, C. G.; Lonsdale, R.; Li, A.; Nett, N.; Hoebenreich, S.; Lingnau, J. B.; Wirtz, C.; Fares, C.; Hinrichs, H. et al.; Deege, A.; Mulholland, A. J.; Nov, Y.; Leys, D.; McLean, K. J.; Munro, A. W.; Reetz, M. T.: P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping. ACS Catalysis 8 (4), S. 3395 - 3410 (2018)

Qu, G.; Lonsdale, R.; Yao, P.; Li, G.; Liu, B.; Reetz, M. T.; Sun, Z.: Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis. Chembiochem 19 (3), S. 239 - 246 (2018)

Sun, Z.; Wu, L.; Bocola, M.; Chan, H. C. S.; Lonsdale, R.; Kong, X.-D.; Yuan, S.; Zhou, J.; Reetz, M. T.: Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. Journal of the American Chemical Society 140 (1), S. 310 - 318 (2018)

Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T.: Correction: Simultaneous engineering of an enzyme’s entrance tunnel and active site: the case of monoamine oxidase MAO-N. Chemical Science 8 (6), S. 4666 - 4666 (2017)

Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T.: Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N. Chemical Science 8 (5), S. 4093 - 4099 (2017)

Muche, S.; Levacheva, I.; Samsonova, O.; Biernasiuk, A.; Malm, A.; Lonsdale, R.; Popiołek, Ł.; Bakowsky, U.; Hołynska, M.: Synthesis, structure and stability of a chiral imine-based Schiff-based ligand derived from L-glutamic acid and its [Cu₄] complex. Journal of Molecular Structure 1127, S. 231 - 236 (2017)

Sun, Z.; Lonsdale, R.; Li, G.; Reetz, M. T.: Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- versus Double-Code Saturation Mutagenesis. Chembiochem 17 (19), S. 1865 - 1872 (2016)

Li, A.; Ilie, A.; Sun, Z.; Lonsdale, R.; Xu, J.-H.; Reetz, M. T.: Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution. Angewandte Chemie International Edition 55 (39), S. 12026 - 12029 (2016)

Sun, Z.; Torres Salas, P.; Siirola, E.; Lonsdale, R.; Reetz, M. T.: Exploring productive sequence space in directed evolution using binary patterning versus conventional mutagenesis strategies. Bioresources and Bioprocessing 3 (44), S. 1 - 8 (2016)

Wang, J.; Lonsdale, R.; Reetz, M. T.: Exploring substrate scope and stereoselectivity of P450 peroxygenase OleTJE in olefin-forming oxidative decarboxylation. Chemical Communications 52, S. 8131 - 8133 (2016)

Sun, Z.; Lonsdale, R.; Ilie, A.; Li, G.; Zhou, J.; Reetz, M. T.: Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple Code Saturation Mutagenesis of an Alcohol Dehydrogenase. ACS Catalysis 6 (3), S. 1598 - 1605 (2016)

Sun, Z.; Lonsdale, R.; Li, G.; Li, A.; Wang, J.; Reetz, M. T.: Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase. ACS Catalysis 6 (3), S. 1590 - 1597 (2016)

Lonsdale, R.; Reetz, M. T.: Reduction of α,β-Unsaturated Ketones by Old Yellow Enzymes: Mechanistic Insights from Quantum Mechanics/Molecular Mechanics Calculations. Journal of the American Chemical Society 137 (46), S. 14733 - 14742 (2015)

Ritter, C.; Nett, N.; Acevedo-Rocha, C. G.; Lonsdale, R.; Kraling, K.; Dempwolff, F.; Hoebenreich, S.; Graumann, P. L.; Reetz, M. T.; Meggers, E.: Bioorthogonal Enzymatic Activation of Caged Compounds. Angewandte Chemie International Edition 54 (45), S. 13440 - 13443 (2015)

Sun, Z.; Lonsdale, R.; Kong, X.-D.; Xu, J.-H.; Zhou, J.; Reetz, M. T.: Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution. Angewandte Chemie International Edition 54 (42), S. 12410 - 12415 (2015)

Ilie, A.; Lonsdale, R.; Agudo Torres, R.; Reetz, M. T.: A diastereoselective P450-catalyzed epoxidation reaction: Anti versus syn reactivity. Tetrahedron Letters 56 (23), S. 3435 - 3437 (2015)

Agudo Torres, R.; Roiban, G.-D.; Lonsdale, R.; Ilie, A.; Reetz, M. T.: Biocatalytic Route to Chiral Acyloins: P450-Catalyzed Regio- and Enantioselective α-Hydroxylation of Ketones. The Journal of Organic Chemistry 80 (2), S. 950 - 956 (2015)

Zhang, Z.-G.; Londsdale, R.; Sanchis-Martinez, J.; Reetz, M. T.: Extreme Synergistic Mutational Effects in the Directed Evolution of a Baeyer–Villiger Monooxygenase as Catalyst for Asymmetric Sulfoxidation. Journal of the American Chemical Society 136 (49), S. 17262 - 17272 (2014)

Roiban, G.-D.; Agudo Torres, R.; Ilie, A.; Londsdale, R.; Reetz, M. T.: CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity. Chemical Communications 50 (92), S. 14310 - 14313 (2014)