Publikationen von Manfred T. Reetz

Li, A.; Qu, G.; Sun, Z.; Reetz, M. T.: Statistical Analysis of the Benefits of Focused Saturation Mutagenesis in Directed Evolution Based on Reduced Amino Acid Alphabets. ACS Catalysis 9 (7), S. 7769 - 7778 (2019)

Cen, Y.; Singh, W.; Arkin, M.; Moody, T. S.; Huang, M.; Zhou, J.; Wu, Q.; Reetz, M. T.: Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. Nature Communications 10, 3198 (2019)

Li, G.; Dong, Y.; Reetz, M. T.: Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes? Advanced Synthesis & Catalysis 361 (11), S. 2377 - 2386 (2019)

Xu, J.; Cen, Y.; Singh, W.; Fan, J.; Wu, L.; Lin, X.; Zhou, J.; Huang, M.; Reetz, M. T.; Wu, Q.: Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters. Journal of the American Chemical Society 141 (19), S. 7934 - 7945 (2019)

Yu, D.; Wang, J.-b.; Reetz, M. T.: Exploiting Designed Oxidase–Peroxygenase Mutual Benefit System for Asymmetric Cascade Reactions. Journal of the American Chemical Society 141 (14), S. 5655 - 5658 (2019)

Dong, Y.; Yao, P.; Cui, Y.; Wu, Q.; Zhu, D.; Li, G.; Reetz, M. T.: Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols. Biological Chemistry 400 (3), S. 313 - 321 (2019)

Reetz, M. T.: Directed Evolution of Artificial Metalloenzymes: A Universal Means to Tune the Selectivity of Transition Metal Catalysts? Accounts of Chemical Research 52 (2), S. 336 - 344 (2019)

Sun, Z.; Liu, Q.; Qu, G.; Feng, Y.; Reetz, M. T.: Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability. Chemical Reviews 119 (3), S. 1626 - 1665 (2019)

Zhou, H.; Wang, B.; Wang, F.; Yu, X.; Ma, L.; Li, A.; Reetz, M. T.: Chemo‐ and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochrome P450 Monooxygenase. Angewandte Chemie International Edition 58 (3), S. 764 - 768 (2019)

Acevedo-Rocha, C. G.; Sun, Z.; Reetz, M. T.: Clarifying the Difference between Iterative Saturation Mutagenesis as a Rational Guide in Directed Evolution and OmniChange as a Gene Mutagenesis Technique. Chembiochem 19 (24), S. 2542 - 2544 (2018)

Cadet, F.; Fontaine, N.; Li, G.; Sanchis, J.; Chong, M. N. F.; Pandjaitan, R.; Vetrivel, I.; Offmann, B.; Reetz, M. T.: A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes. Scientific Reports 8, 16757 (2018)

Li, A.; Sun, Z.; Reetz, M. T.: Solid‐Phase Gene Synthesis for Mutant Library Construction: The Future of Directed Evolution? Chembiochem 19 (19), S. 2023 - 2032 (2018)

She, W.; Ni, J.; Shui, K.; Wang, F.; He, R.; Xue, J.; Reetz, M. T.; Li, A.; Ma, L.: Rapid and Error-Free Site-Directed Mutagenesis by a PCR-Free In Vitro CRISPR/Cas9-Mediated Mutagenic System. ACS Synthetic Biology 7 (9), S. 2236 - 2244 (2018)

Li, G.; Garcia-Borràs, M.; Fürst, M. J.L.J.; Ilie, A.; Fraaije, M. W.; Houk, K. N.; Reetz, M. T.: Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution. Journal of the American Chemical Society 140 (33), S. 10464 - 10472 (2018)

Ilie, A.; Harms, K.; Reetz, M. T.: P450-Catalyzed Regio- and Stereoselective Oxidative Hydroxylation of 6-Iodotetralone: Preparative-Scale Synthesis of a Key Intermediate for Pd-Catalyzed Transformations. The Journal of Organic Chemistry 83 (14), S. 7504 - 7508 (2018)

König, G.; Reetz, M. T.; Thiel, W.: 1-Butanol as a Solvent for Efficient Extraction of Polar Compounds from Aqueous Medium: Theoretical and Practical Aspects. The Journal of Physical Chemistry B 122 (27), S. 6975 - 6988 (2018)

Schrimpf, A.; Hempel, F.; Li, A.; Linne, U.; Maier, U. G.; Reetz, M. T.; Geyer, A.: Hinge-Type Dimerization of Proteins by a Tetracysteine Peptide of High Pairing Specificity. Biochemistry 57 (26), S. 3658 - 3664 (2018)

Li, A.; Acevedo-Rocha, C. G.; Reetz, M. T.: Boosting the efficiency of site-saturation mutagenesis for a difficult-to-randomize gene by a two-step PCR strategy. Applied Microbiology and Biotechnology 102 (14), S. 6095 - 6103 (2018)

Acevedo-Rocha, C. G.; Gamble, C. G.; Lonsdale, R.; Li, A.; Nett, N.; Hoebenreich, S.; Lingnau, J. B.; Wirtz, C.; Fares, C.; Hinrichs, H. et al.; Deege, A.; Mulholland, A. J.; Nov, Y.; Leys, D.; McLean, K. J.; Munro, A. W.; Reetz, M. T.: P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping. ACS Catalysis 8 (4), S. 3395 - 3410 (2018)

Li, G.; Wang, J.; Reetz, M. T.: Biocatalysts for the pharmaceutical industry created by structure-guided directed evolution of stereoselective enzymes. Bioorganic & Medicinal Chemistry 26 (7), S. 1241 - 1251 (2018)