Publikationen von Manfred T. Reetz

Zeitschriftenartikel (300)

2022
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Reetz, M. T.: Making Enzymes Suitable for Organic Chemistry by Rational Protein Design. Chembiochem 23 (14), e202200049 (2022)
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Reetz, M. T.: Witnessing the Birth of Directed Evolution of Stereoselective Enzymes as Catalysts in Organic Chemistry. Advanced Synthesis & Catalysis (2022)
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Dong, Y.; Li, T.; Zhang, S.; Sanchis, J.; Yin, H.; Ren, J.; Sheng, X.; Li, G.; Reetz, M. T.: Biocatalytic Baeyer–Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates. ACS Catalysis 12 (6), S. 3669 - 3680 (2022)
2021
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Reetz, M. T.; König, G.: n-Butanol: An Ecologically and Economically Viable Extraction Solvent for Isolating Polar Products from Aqueous Solutions. European Journal of Organic Chemistry 2021 (46), S. 6224 - 6228 (2021)
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Reetz, M. T.: Effective Mentoring and the Problem of Assessing Quality in Science. Helvetica Chimica Acta 104 (10), e2100124 (2021)
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Reetz, M. T.; Garcia-Borràs, M.: The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions. Journal of the American Chemical Society 143 (37), S. 14939 - 14950 (2021)
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Acevedo-Rocha, C. G.; Li, A.; D'Amore, L.; Hoebenreich, S.; Sanchis, J.; Lubrano, P.; Ferla, M. P.; Garcia-Borràs, M.; Osuna, S.; Reetz, M. T.: Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics. Nature Communications 12 (1), 1621 (2021)
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Li, G.; Qin, Y.; Fontaine, N. T.; Ng Fuk Chong, M.; Maria-Solano, M. A.; Feixas, F.; Cadet, X. F.; Pandjaitan, R.; Garcia‐Borràs, M.; Cadet, F. et al.; Reetz, M. T.: Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation. Chembiochem 22 (5), S. 904 - 914 (2021)
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Reetz, M. T.: A breakthrough in protein engineering of a glycosyltransferase. Green Synthesis and Catalysis 2 (1), S. 4 - 5 (2021)
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Lehmann, U.; Goddard, R.; Tonner, R.; Reetz, M. T.: Towards self-doping multimetal porphyrin systems. Journal of Porphyrins and Phthalocyanines 25 (2), S. 162 - 167 (2021)
2020
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Reetz, M. T.: Effective mentoring ensures the progress of science. Journal of Biology 37 (6) (2020)
Zeitschriftenartikel
Qu, G.; Li, A.; Acevedo-Rocha, C. G.; Sun, Z.; Reetz, M. T.: The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes. Angewandte Chemie, International Edition 59 (32), S. 13204 - 13231 (2020)
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Li, A.; Acevedo-Rocha, C. G.; D'Amore, L.; Chen, J.; Peng, Y.; Garcia‐Borràs, M.; Gao, C.; Zhu, J.; Rickerby, H.; Osuna, S. et al.; Zhou, J.; Reetz, M. T.: Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants. Angewandte Chemie International Edition 59 (30), S. 12499 - 12505 (2020)
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Wang, J.-b.; Huang, Q.; Peng, W.; Wu, P.; Yu, D.; Chen, B.; Wang, B.; Reetz, M. T.: P450-BM3-Catalyzed Sulfoxidation versus Hydroxylation: A Common or Two Different Catalytically Active Species? Journal of the American Chemical Society 142 (4), S. 2068 - 2073 (2020)
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Wu, Q.; Reetz, M. T.: Are Cysteine-lipases Involved in the Immune System? Journal of Cellular Immunology 2 (4), S. 175 - 177 (2020)
2019
Zeitschriftenartikel
Zhou, H.; Zhao, J.; Li, A.; Reetz, M. T.: Chemical and Biocatalytic Routes to Arbutin. Molecules 24 (18), 3303 (2019)
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Li, A.; Qu, G.; Sun, Z.; Reetz, M. T.: Statistical Analysis of the Benefits of Focused Saturation Mutagenesis in Directed Evolution Based on Reduced Amino Acid Alphabets. ACS Catalysis 9 (7), S. 7769 - 7778 (2019)
Zeitschriftenartikel
Cen, Y.; Singh, W.; Arkin, M.; Moody, T. S.; Huang, M.; Zhou, J.; Wu, Q.; Reetz, M. T.: Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. Nature Communications 10, 3198 (2019)
Zeitschriftenartikel
Li, G.; Dong, Y.; Reetz, M. T.: Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes? Advanced Synthesis & Catalysis 361 (11), S. 2377 - 2386 (2019)
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Xu, J.; Cen, Y.; Singh, W.; Fan, J.; Wu, L.; Lin, X.; Zhou, J.; Huang, M.; Reetz, M. T.; Wu, Q.: Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters. Journal of the American Chemical Society 141 (19), S. 7934 - 7945 (2019)
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