Publikationen von Manfred T. Reetz

Hollmann, F.; Sanchis Martinez, J.; Reetz, M. T. Learning from Protein Engineering by Deconvolution of Multi-Mutational Variants. Angewandte Chemie International Edition 2024, e202404880.

Mei, Z.-L.; Li, C.-C.; Han, X.; Tian, Y.-C.; Li, S.-H.; Liu, W.; Qu, G.; Reetz, M. T.; Sun, Z.; Ma, J.-A.; Zhang, F.-G. Enzymatic Stereodivergent Access to Fluorinated β-Lactam Pharmacophores via Triple-Parameter Engineered Ketoreductases. ACS Catalysis 2024, 14, 6358–6368.

Reetz, M. T.; Qu, G.; Sun, Z. Engineered enzymes for the synthesis of pharmaceuticals and other high-value products. Nature Synthesis 2024, 3, 19–32.

Reetz, M. T.; Hollmann, F. Breakthrough in the challenging P450-catalyzed chemoenzymatic synthesis of C14-functionalized steroids. Science China Chemistry 2023, 66, 2435–2436.

Reetz, M. T. Dyotropic Rearrangements in Organic Solvents, in the Gas Phase, and in Enzyme Catalysis. Israel Journal of Chemistry 2023, 63, e202200122.

Li, A.; Wang, Q.; Song, X.; Zhang, X.; Huang, J.-W.; Chen, C.-C.; Guo, R.-T.; Wang, B.; Reetz, M. T. Engineering of a P450-based Kemp eliminase with a new mechanism. Chinese Journal of Catalysis 2023, 47, 191–199.

Li, J.-K.; Qu, G.; Li, X.; Tian, Y.; Cui, C.; Zhang, F.-G.; Zhang, W.; Ma, J.-A.; Reetz, M. T.; Sun, Z. Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles. Nature Communications 2022, 13, 7813.

Reetz, M. T. Witnessing the Birth of Directed Evolution of Stereoselective Enzymes as Catalysts in Organic Chemistry. Advanced Synthesis & Catalysis 2022, 364, 3326–3335.

Reetz, M. T. Making Enzymes Suitable for Organic Chemistry by Rational Protein Design. Chembiochem 2022, 23, e202200049.

Dong, Y.; Li, T.; Zhang, S.; Sanchis, J.; Yin, H.; Ren, J.; Sheng, X.; Li, G.; Reetz, M. T. Biocatalytic Baeyer–Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates. ACS Catalysis 2022, 12, 3669–3680.

Reetz, M. T.; König, G. n-Butanol: An Ecologically and Economically Viable Extraction Solvent for Isolating Polar Products from Aqueous Solutions. European Journal of Organic Chemistry 2021, 2021, 6224–6228.

Reetz, M. T. Effective Mentoring and the Problem of Assessing Quality in Science. Helvetica Chimica Acta 2021, 104, e2100124.

Reetz, M. T.; Garcia-Borràs, M. The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions. Journal of the American Chemical Society 2021, 143, 14939–14950.

Acevedo-Rocha, C. G.; Li, A.; D'Amore, L.; Hoebenreich, S.; Sanchis, J.; Lubrano, P.; Ferla, M. P.; Garcia-Borràs, M.; Osuna, S.; Reetz, M. T. Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics. Nature Communications 2021, 12, 1621.

Li, G.; Qin, Y.; Fontaine, N. T.; Ng Fuk Chong, M.; Maria-Solano, M. A.; Feixas, F.; Cadet, X. F.; Pandjaitan, R.; Garcia‐Borràs, M.; Cadet, F.; Reetz, M. T. Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation. Chembiochem 2021, 22, 904–914.

Reetz, M. T. A breakthrough in protein engineering of a glycosyltransferase. Green Synthesis and Catalysis 2021, 2, 4–5.

Lehmann, U.; Goddard, R.; Tonner, R.; Reetz, M. T. Towards self-doping multimetal porphyrin systems. Journal of Porphyrins and Phthalocyanines 2021, 25, 162–167.

Reetz, M. T. Effective mentoring ensures the progress of science. Journal of Biology 2020, 37.

Qu, G.; Li, A.; Acevedo-Rocha, C. G.; Sun, Z.; Reetz, M. T. The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes. Angewandte Chemie, International Edition 2020, 59, 13204–13231.

Li, A.; Acevedo-Rocha, C. G.; D'Amore, L.; Chen, J.; Peng, Y.; Garcia‐Borràs, M.; Gao, C.; Zhu, J.; Rickerby, H.; Osuna, S.; Zhou, J.; Reetz, M. T. Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants. Angewandte Chemie International Edition 2020, 59, 12499–12505.