We explore small-molecule amines as asymmetric catalysts for carbonyl transformations. “Asymmetric Aminocatalysis” functions by activating carbonyl compounds as iminium ions and enamines using a catalytic amount of an amine. Our strategy complements....[more]
Due to the vast number of reactions that can be catalyzed by Brønsted acids, a core area of our research focuses on the development and application of chiral organic Brønsted acids for asymmetric counteranion-directed catalysis (ACDC). To date... [more]
To date, the field of Lewis acid catalysis has been dominated by (transition) metal chemistry. To provide purely organic counterparts to these traditional catalytic systems we are dedicated to the synthesis and identification of organic Lewis acids. In 2009, we demonstrated that our chiral disulfonimides (DSI) are not only excellent Brønsted acids, but form strong Lewis acids upon silylation.[more]
