Cisplatin-related Metal Complexes
Among the most prominent anti-cancer drugs are cisplatin, carboplatin, and oxaliplatin. Therapy with these drugs is frequently associated with serious side-effects, and inherent or acquired platinum resistance is a major problem. Thus, there is an unabated need for remedy and probing new structures. We have studied parent bispidine (3,7-diazabicyclo[3.3.1]nonane, C7H14N2) and its derivatives, substituted at the remote 9-position, for usage as “carrier ligands” for Pt(II). The studies allow insight into parameters such as hydrogen-bonding, association, hydration, water solubility, and polarity of the complexes, relevant to cytostatic potency.