Total Synthesis and Evaluation of Natural Products

We are dedicated to the application of organometallic catalysis to the total synthesis of structurally complex natural products of biological significance; where indicated, we are also committed to prepare analogues by “diverted total synthesis” for biological and/or pharmacological evaluation.

From the chemical viewpoint, most projects intend to scrutinize the synthetic methods of interest to our group. We wish to develop syntheses that are concise, convergent, productive and scalable; ideally, they should be largely catalysis-based and require a minimum of protecting group manipulations. With regard to the targets, our choice is usually based on structural considerations, biological activity, and non-availability of meaningful amounts from the natural sources. Biological assessments of the compounds prepared in the laboratory are carried out in collaboration with external partners.

Additional information can be found in the following presentation.

Gallery of Natural Product Synthesis
of the Department of Organometallic Chemistry more
Go to Editor View