Publications of Manfred T. Reetz

Li, A.; Acevedo-Rocha, C. G.; Reetz, M. T.: Boosting the efficiency of site-saturation mutagenesis for a difficult-to-randomize gene by a two-step PCR strategy. Applied Microbiology and Biotechnology 102 (14), pp. 6095 - 6103 (2018)

Acevedo-Rocha, C. G.; Gamble, C. G.; Lonsdale, R.; Li, A.; Nett, N.; Hoebenreich, S.; Lingnau, J. B.; Wirtz, C.; Fares, C.; Hinrichs, H. et al.; Deege, A.; Mulholland, A. J.; Nov, Y.; Leys, D.; McLean, K. J.; Munro, A. W.; Reetz, M. T.: P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping. ACS Catalysis 8 (4), pp. 3395 - 3410 (2018)

Li, G.; Wang, J.; Reetz, M. T.: Biocatalysts for the pharmaceutical industry created by structure-guided directed evolution of stereoselective enzymes. Bioorganic & Medicinal Chemistry 26 (7), pp. 1241 - 1251 (2018)

Li, A.; Acevedo-Rocha, C. G.; Sun, Z.; Cox, T.; Xu, J. L.; Reetz, M. T.: Beating Bias in the Directed Evolution of Proteins: Combining High-Fidelity on-Chip Solid-Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction. Chembiochem 19 (3), pp. 221 - 228 (2018)

Qu, G.; Lonsdale, R.; Yao, P.; Li, G.; Liu, B.; Reetz, M. T.; Sun, Z.: Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis. Chembiochem 19 (3), pp. 239 - 246 (2018)

Reetz, M. T.: Combinatorial Libraries Reloaded^[1]. Israel Journal of Chemistry 58 (1-2), pp. 52 - 60 (2018)

Sun, Z.; Wu, L.; Bocola, M.; Chan, H. C. S.; Lonsdale, R.; Kong, X.-D.; Yuan, S.; Zhou, J.; Reetz, M. T.: Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. Journal of the American Chemical Society 140 (1), pp. 310 - 318 (2018)

Li, G.; Fürst, M. J. L. J.; Mansouri, H. R.; Ressmann, A. K.; Ilie, A.; Rudroff, F.; Mihovilovic, M. D.; Fraaije, M. W.; Reetz, M. T.: Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution. Organic & Biomolecular Chemistry 15 (46), pp. 9824 - 9829 (2017)

Li, G.; Maria-Solano, M. A.; Romero-Rivera, A.; Osuna, S.; Reetz, M. T.: Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution. Chemical Communications 53 (68), pp. 9454 - 9457 (2017)

Wang, J.; Ilie, A.; Yuan, S.; Reetz, M. T.: Investigating Substrate Scope and Enantioselectivity of a Defluorinase by a Stereochemical Probe. Journal of the American Chemical Society 139 (32), pp. 11241 - 11247 (2017)

Wang, J.; Ilie, A.; Reetz, M. T.: Chemo- and Stereoselective Cytochrome P450-BM3 Catalyzed Sulfoxidation of 1-Thiochroman-4-ones. Advanced Synthesis & Catalysis 359 (12), pp. 2056 - 2060 (2017)

Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T.: Correction: Simultaneous engineering of an enzyme’s entrance tunnel and active site: the case of monoamine oxidase MAO-N. Chemical Science 8 (6), p. 4666 - 4666 (2017)

Acevedo, J. P.; Reetz, M. T.; Asenjo, J. A.; Parra, L. P.: One-Step Combined Focused epPCR and Saturation Mutagenesis for Thermostability Evolution of a New Cold-Active Xylanase. Enzyme and Microbial Technology 100 (5), pp. 60 - 70 (2017)

Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T.: Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N. Chemical Science 8 (5), pp. 4093 - 4099 (2017)

Wang, J.; Li, G.; Reetz, M. T.: Enzymatic site-selectivity enabled by structure-guided directed evolution. Chemical Communications 53 (28), pp. 3916 - 3928 (2017)

Li, A.; Wang, B.; Ilie, A.; Dubey, K. D.; Bange, G.; Korendovych, I. V.; Shaik, S.; Reetz, M. T.: A redox-mediated Kemp eliminase. Nature Communications 8, 14876 (2017)

Qiao, Y.; Theyssen, N.; Eifert , T.; Liauw, M. A.; Francio, G.; Schenk , K.; Leitner, W.; Reetz, M. T.: Concerning the Role of Supercritical Carbon Dioxide in SN₁ Reactions. Chemistry – A European Journal 23 (16), pp. 3898 - 3902 (2017)

Ilie, A.; Roiban, G.-D.; Reetz, M. T.: Di–tert–butyl N,N-diethylphosphoramidite as an Air Stable Ligand for Suzuki-Miyaura and Buchwald-Hartwig Reactions. ChemistrySelect 2 (4), pp. 1392 - 1397 (2017)

Luo, X.-J.; Zhao, J.; Li, C.-X.; Bai, Y.-P.; Reetz, M. T.; Yu, H.-L.; Xu, J.-H.: Combinatorial evolution of phosphotriesterase toward a robust malathion degrader by hierarchical iteration mutagenesis. Biotechnology and Bioengineering 113 (11), pp. 2350 - 2357 (2016)

Sun, Z.; Lonsdale, R.; Li, G.; Reetz, M. T.: Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- versus Double-Code Saturation Mutagenesis. Chembiochem 17 (19), pp. 1865 - 1872 (2016)