Publications of Manfred T. Reetz

Ilie, A.; Lonsdale, R.; Agudo Torres, R.; Reetz, M. T. A Diastereoselective P450-Catalyzed Epoxidation Reaction: Anti Versus Syn Reactivity. Tetrahedron Letters 2015, 56, 3435–3437.

Parra, L. P.; Acevedo, J. P.; Reetz, M. T. Directed Evolution of Phenylacetone Monooxygenase as an Active Catalyst for the Baeyer-Villiger Conversion of Cyclohexanone to Caprolactone. Biotechnology and Bioengineering 2015, 1354–1364.

Ilie, A.; Agudo Torres, R.; Roiban, G.-D.; Reetz, M. T. P450-Catalyzed Regio- and Stereoselective Oxidative Hydroxylation of Disubstituted Cyclohexanes: Creation of Three Centers of Chirality in a Single CH-Activation Event. Tetrahedron 2015, 71, 470–475.

Agudo Torres, R.; Roiban, G.-D.; Lonsdale, R.; Ilie, A.; Reetz, M. T. Biocatalytic Route to Chiral Acyloins: P450-Catalyzed Regio- and Enantioselective α-Hydroxylation of Ketones. The Journal of Organic Chemistry 2015, 80, 950–956.

Höbenreich, S.; Zilly, F.; Acevedo-Rocha, C. G.; Zilly, M.; Reetz, M. T. Speeding up Directed Evolution: Combining the Advantages of Solid-Phase Combinatorial Gene Synthesis with Statistically Guided Reduction of Screening Effort. ACS Synthetic Biology 2015, 317–331.

Ilie, A.; Reetz, M. T. Directed Evolution of Artificial Metalloenzymes. Israel Journal of Chemistry 2015, 55, 51–60.

Roiban, G.-D.; Reetz, M. T. Expanding the Toolbox of Organic Chemists: Directed Evolution of P450 Monooxygenases as Catalysts in Regio- and Stereoselective Oxidative Hydroxylation. Chemical Communications 2015, 51, 2208–2224.

Roiban, G.-D.; Ilie, A.; Reetz, M. T. The Chelation-Controlled Mukaiyama Aldol Reaction of Chiral α- and β-Alkoxy Aldehydes. Chemistry Letters 2014, 43 (2014), 2–10.

Acevedo-Rocha, C. G.; Agudo Torres, R.; Reetz, M. T. Directed Evolution of Stereoselective Enzymes Based on Genetic Selection as Opposed to Screening Systems. Journal of Biotechnology 2014, 191, 3–10.

Zhang, Z.-G.; Londsdale, R.; Sanchis-Martinez, J.; Reetz, M. T. Extreme Synergistic Mutational Effects in the Directed Evolution of a Baeyer–Villiger Monooxygenase as Catalyst for Asymmetric Sulfoxidation. Journal of the American Chemical Society 2014, 136, 17262–17272.

Roiban, G.-D.; Agudo Torres, R.; Ilie, A.; Londsdale, R.; Reetz, M. T. CH-Activating Oxidative Hydroxylation of 1-Tetralones and Related Compounds with High Regio- and Stereoselectivity. Chemical Communications 2014, 50, 14310–14313.

Reetz, M. T. One Hundred Years of the Max‐Planck‐Institut für Kohlenforschung. Angewandte Chemie International Edition 2014, 53, 8562–8586.

Roiban, G.-D.; Agudo Torres, R.; Reetz, M. T. Cytochrome P450 Catalyzed Oxidative Hydroxylation of Achiral Organic Compounds with Simultaneous Creation of Two Chirality Centers in a Single C-H Activation Step. Angewandte Chemie International Edition 2014, 53, 8659–8663.

Roiban, G.-D.; Mehler, G.; Reetz, M. T. Palladium-Catalysed Amination of Aryl- and Heteroaryl Halides Using Tert-Butyl Tetraisopropylphosphorodiamidite as an Easily Accessible and Air-Stable Ligand. European Journal of Organic Chemistry 2014, 2014, 2070–2076.

Tielmann, P.; Kierkels, H.; Zonta, A.; Ilie, A.; Reetz, M. T. Increasing the Activity and Enantioselectivity of Lipases by Sol–Gel Immobilization: further Advancements of Practical Interest. Nanoscale 2014, 12, 6220–6228.

Parra, L. P.; Agudo Torres, R.; Reetz, M. T. Directed Evolution by Using Iterative Saturation Mutagenesis Based on Multiresidue Sites. ChemBioChem: A European Journal of Chemical Biology 2013, 14, 2301–2309.

Reetz, M. T. Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future. Journal of the American Chemical Society 2013, 135, 12480–12496.

Roiban, G.-D.; Agudo Torres, R.; Reetz, M. T. Stereo- and Regioselectivity in the P450-Catalyzed Oxidative Tandem Difunctionalization of 1-Methylcyclohexene. Tetrahedron 2013, 69, 5306–5311.

Roiban, G.-D.; Reetz, M. T. Enzyme Promiscuity: Using a P450 Enzyme as a Carbene Transfer Catalyst. Angewandte Chemie International Edition: a journal of the Gesellschaft Deutscher Chemiker 2013, 52, 5439–5440.

Polyak, I.; Reetz, M. T.; Thiel, W. Quantum Mechanical/Molecular Mechanical Study on the Enantioselectivity of the Enzymatic Baeyer–Villiger Reaction of 4-Hydroxycyclohexanone. The Journal of Physical Chemistry B 2013, 117, 4993–5001.