Publications of Manfred T. Reetz

Sun, Z.; Li, G.; Ilie, A.; Reetz, M. T. Exploring the Substrate Scope of Mutants Derived from the Robust Alcohol Dehydrogenase TbSADH. Tetrahedron Letters 2016, 57, 3648–3651.

Wang, J.; Lonsdale, R.; Reetz, M. T. Exploring Substrate Scope and Stereoselectivity of P450 Peroxygenase OleTJE in Olefin-Forming Oxidative Decarboxylation. Chemical Communications 2016, 52, 8131–8133.

Li, G.; Reetz, M. T. Learning Lessons from Directed Evolution of Stereoselective Enzymes. Organic Chemistry Frontiers 2016, 3, 1350–1358.

Reetz, M. T. What are the Limitations of Enzymes in Synthetic Organic Chemistry? The Chemical Record 2016.

Li, G.; Zhang, H.; Sun, Z.; Liu, X.; Reetz, M. T. Multiparameter Optimization in Directed Evolution: Engineering Thermostability, Enantioselectivity, and Activity of an Epoxide Hydrolase. ACS Catalysis 2016, 6, 3679–3687.

Sun, Z.; Wikmark, Y.; Backvall, J.-E.; Reetz, M. T. New Concepts for Increasing the Efficiency in Directed Evolution of Stereoselective Enzymes. Chemistry – A European Journal 2016, 22, 5046–5054.

Krone, K. M.; Warias, R.; Ritter, C.; Li, A.; Acevedo-Rocha, C. G.; Reetz, M. T.; Belder, D. Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip. Journal of the American Chemical Society 2016, 138, 2102–2105.

Sun, Z.; Lonsdale, R.; Ilie, A.; Li, G.; Zhou, J.; Reetz, M. T. Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple Code Saturation Mutagenesis of an Alcohol Dehydrogenase. ACS Catalysis 2016, 6, 1598–1605.

Sun, Z.; Lonsdale, R.; Li, G.; Li, A.; Wang, J.; Reetz, M. T. Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase. ACS Catalysis 2016, 6, 1590–1597.

Wu, Z.; Reetz, M. T.; Harms, K. Crystal Structure of 7,8,9,10-Tetrahydro-Benzo[b]-Naphtho[2,1-d]Furan. Acta Crystallographica, Section E: Crystal Structure Communications 2016, 72, 106–108.

Wang, J.; Reetz, M. T. Biocatalysis: Chiral Cascades. Nature Chemistry 2015, 7, 948–949.

Lonsdale, R.; Reetz, M. T. Reduction of α,β-Unsaturated Ketones by Old Yellow Enzymes: Mechanistic Insights from Quantum Mechanics/Molecular Mechanics Calculations. Journal of the American Chemical Society 2015, 137, 14733–14742.

Lonsdale, R.; Reetz, M. T. Reduction of α,β-Unsaturated Ketones by Old Yellow Enzymes: Mechanistic Insights from Quantum Mechanics/Molecular Mechanics Calculations. Journal of the American Chemical Society 2015, 137, 14733–14742.

Keinan, E.; Diesendruck, C.; Reetz, M. T. A 50-Year Long Lesson. A 50-Year Long Lesson 2015, 55, 1154–1155.

Ritter, C.; Nett, N.; Acevedo-Rocha, C. G.; Lonsdale, R.; Kraling, K.; Dempwolff, F.; Hoebenreich, S.; Graumann, P. L.; Reetz, M. T.; Meggers, E. Bioorthogonal Enzymatic Activation of Caged Compounds. Angewandte Chemie International Edition 2015, 54, 13440–13443.

Sun, Z.; Lonsdale, R.; Kong, X.-D.; Xu, J.-H.; Zhou, J.; Reetz, M. T. Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution. Angewandte Chemie International Edition 2015, 54, 12410–12415.

Sun, Z.; Lonsdale, R.; Kong, X.-D.; Xu, J.-H.; Zhou, J.; Reetz, M. T. Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution. Angewandte Chemie International Edition 2015, 54, 12410–12415.

Reetz, M. T.; Sun, Z.; Ilie, A. Towards the Production of Universal Blood by Structure-Guided Directed Evolution of Glycoside Hydrolases. Angewandte Chemie International Edition 2015, 54, 9158–9160.

Acevedo-Rocha, C. G.; Reetz, M. T.; Nov, Y. Economical Analysis of Saturation Mutagenesis Experiments. Scientific Reports 2015, 5, 10654.

Ilie, A.; Lonsdale, R.; Agudo Torres, R.; Reetz, M. T. A Diastereoselective P450-Catalyzed Epoxidation Reaction: Anti Versus Syn Reactivity. Tetrahedron Letters 2015, 56, 3435–3437.