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Organometallic Chemistry

The research in the Department of Organometallic Chemistry is focused on the development and understanding of organometallic reagents and catalysts, as well as on their application to the synthesis of structurally complex targets of biological significance. Particular attention is paid to the development and validation of catalytic methods for C-C-bond formation. Long term projects of current interest concern alkene and alkyne metathesis, the development and use of pi-acids (platinum, gold etc.), iron catalysis and cross coupling in general.

Moreover, the group is engaged in the development of novel donor ligands, including carbenes and compounds containing formally "zerovalent" carbon atoms. All methods are scrutinized by applications to the total synthesis and "diverted total synthesis" of natural products and pharmaceutically active compounds.

Alois Fürstner

Prof. Dr. Alois Fürstner

2009-2011
Managing Director of the Max-Planck-Institut für Kohlenforschung
since 1998
Director at the Max-Planck-Institut für Kohlenforschung and Professor at the Technical University of Dortmund
1993-1998
Group leader at the Max-Planck-Institut für Kohlenforschung and Lecturer at the University of Dortmund
1992
“Habilitation” in Organic Chemistry at the Technical University Graz, Austria
1990-1991
Postdoctoral fellow at the University of Geneva, Switzerland (W. Oppolzer)
1987
PhD at the Technical University Graz, Austria (H. Weidmann)
1962
born in Bruck/Mur (Austria)
2014
Gay-Lussac-Humboldt Prize
2014
Hans Herloff Inhoffen Medal
2013
Kitasato Medal, Tokyo, Japan
2013
Karl Ziegler Prize of the German Chemical Society
2013
Prix Jaubert of the University of Geneva
2011
Prelog Medal, ETH Zurich, Switzerland
2011
Lilly European Distinguished Lectureship Award
2008
Janssen Pharmaceutica Prize for Creativity in Organic Synthesis
2006
Heinrich Wieland Prize
2006
Otto Bayer Prize
2005
Mukaiyama Award, Society of Synthetic Organic Chemistry, Japan
2005
Junior Award, International Society of Heterocyclic Chemistry
2004
Tetrahedron Chair
since 2004
Corresponding Member of the Österreichische Akademie der Wissenschaften
since 2004
Member of the Nordrhein-Westfälische Akademie der Wissenschaften
2004
Centenary Lecture, Royal Society of Chemistry
2002
Arthur C. Cope Scholar Award, American Chemical Society
2002
Merck Academic Development Program Award
since 2002
Member of the Deutsche Akademie der Naturforscher Leopoldina
2001
Victor Grignard - Georg Wittig Prize, Société Française de Chimie
2000
AstraZeneca Award in Organic Chemistry
2000
Thieme-IUPAC Prize in Synthetic Organic Chemistry
1999
Leibniz Award, German Science Foundation (DFG)
1999
Invited Professor at the Ecole Normale Supérieure, Paris, France
1998
Ruhr Prize for Arts and Sciences, Mülheim/Ruhr
1994
Invited Professor at the Université Claude Bernard - Lyon I, France
1994
Lecturer's scholarship ("Dozentenstipendium"), Fonds der Chemischen Industrie
since 2014
Chairman of the Editorial Board of "Angewandte Chemie"
since 2014
Senior Editor "Bulletin of the Chemical Society of Japan" (BCSJ)
since 2012
Member of the Scientific Advisory Board at the Institute of Chemical Research of Catalonia (ICIQ)
since 2010
Member of the Selection Committee of the Heinrich Wieland Prize
since 2008
Member of the Editorial Board of "Science of Synthesis" (formerly "Houben-Weyl")Knowledge Updates
2008
Member of the Search Committee, Institute of Science and Technology Austria (ISTA)
since 2007
Member of the Selection Committee of the Otto-Hahn-Prize of the GdCH
2006-2010
Chairman of the Selection Committee of the Alexander von Humboldt-Foundation, Feodor-Lynen-Program
2004-2011
Member of the Board of Governors of the Gesellschaft Deutscher Chemiker (GDCh)
2002-2010
Member of the Selection Committee of the Alexander von Humboldt-Foundation, Feodor-Lynen-Program
2002-2009
Member of the Scientific Advisory Board at the Institut für Organische Katalyseforschung Rostock, since 2003 Leibniz-Institute for Organic Catalysis at the University of Rostock
2001-2007
Scientific Editor of "Chemical Communications"
2001-2006
Member of the Board of Editors of "Organic Syntheses"
2014

G. Seidel, A. Fürstner
Structure of a Reactive Gold Carbenoid.
Angew. Chem., Int. Ed. 2014, DOI: 10.1002/anie.201402080.

J. Willwacher, A. Fürstner
Catalysis-based Total Synthesis of Putative Mandelalide A.
Angew. Chem., Int. Ed. 2014, DOI: 10.1002/anie.201400605.

L. Hoffmeister, P. Persich, A. Fürstner
Formal Total Synthesis of Kendomycin by Way of Alkyne Metathesis/Gold Catalysis.
Chem.–Eur. J. 2014, 20, 4396-4402.

S. M. Rummelt, A. Fürstner
Ruthenium-Catalyzed trans-Selective Hydrostannation of Alkynes.
Angew. Chem., Int. Ed. 2014, 53, 3626-3630.

A. Fürstner
From Understanding to Prediction: Gold- and Platinum-Based π-Acid Catalysis for Target Oriented Synthesis.
Acc. Chem. Res. 2014, 47, 925-938.

A. Fürstner
Alkyne Metathesis.
In: Comprehensive Organic Synthesis, 2nd Ed., Vol. 5 (G. A. Molander, P. Knochel, Eds.), Elsevier, Oxford, 2014, pp. 1357-1399.

G. Seidel, B. Gabor, R. Goddard, B. Heggen, W. Thiel, A. Fürstner
Gold Carbenoids: Lessons Learnt from a Transmetalation Approach.
Angew. Chem., Int. Ed. 2014, 53, 879-882.

A. Fürstner
What Matters?
Angew. Chem., Int. Ed
. 2014, 53, 8-9.

2013

B. Sundararaju, A. Fürstner
A trans-Selective Hydroboration of Internal Alkynes.
Angew. Chem., Int. Ed. 2013, 52, 14050-14054.

C.-L. Sun, A. Fürstner
Formal Ring Opening/Cross-Coupling Reactions of 2-Pyrones: Iron-Catalyzed Entry into Stereodefined Dienyl Carboxylates.
Angew. Chem., Int. Ed. 2013, 52, 13071-13075.

P. Persich, J. Llaveria, R. Lhermet, T. de Haro, R. Stade, A. Kondoh, A. Fürstner
Increasing the Structural Span of Alkyne Metathesis.
Chem.–Eur. J. 2013, 19, 13047-13058.

A. Fürstner
Teaching Metathesis “Simple” Stereochemistry.
Science 2013, 341, 1229713.

G. Valot, C. S. Regens, D. P. O’Malley, E. Godineau, H. Takikawa, A. Fürstner
Total Synthesis of Amphidinolide F.
Angew. Chem., Int. Ed. 2013, 52, 9534-9538.

A. Kondoh, A. Arlt, B. Gabor, A. Fürstner
Total Synthesis of Nominal Gobienine A.
Chem.–Eur. J. 2013, 19, 7731-7738.

K. Micoine, P. Persich, J. Llaveria, M.-H. Lam, A. Maderna, F. Loganzo, A. Fürstner,
Total Syntheses and Biological Reassessment of Lactimidomycin, Isomigrastatin and Congener Glutarimide Antibiotics.
Chem.–Eur. J. 2013, 19, 7370-7383.

M. Alcarazo, K. Radkowski, G. Mehler, R. Goddard, A. Fürstner
Chiral Heterobimetallic Complexes of Carbodiphosphoranes and Phosphinidene–Carbene Adducts.
Chem. Commun. (Cambridge, U. K.) 2013, 49, 3140-3142.

L. Brewitz, J. Llaveria, A. Yada, A. Fürstner
Formal Total Synthesis of the Algal Toxin (−)-Polycavernoside A.
Chem.–Eur. J. 2013, 19, 4532-4537.

A. Arlt, S. Benson, S. Schulthoff, B. Gabor, A. Fürstner
A Total Synthesis of Spirastrellolide A Methyl Ester.
Chem.–Eur. J. 2013, 19, 3596-3608.

A. Fürstner
Alkyne Metathesis on the Rise.
Angew. Chem., Int. Ed. 2013, 52, 2794-2819.

K. Radkowski, B. Sundararaju, A. Fürstner
A  Functional-Group-Tolerant Catalytic trans Hydrogenation of Alkynes.
Angew. Chem., Int. Ed. 2013, 52, 355-360.

2012

J. Willwacher, N. Kausch-Busies, A. Fürstner
Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide.
Angew. Chem., Int. Ed. 2012, 51, 12041-12046.

H. Teller, M. Corbet, L. Mantilli, G. Gopakumar, R. Goddard, W. Thiel, A. Fürstner
One-Point Binding Ligands for Asymmetric Gold Catalysis: Phosphoramidites with a TADDOL-Related but Acyclic Backbone.
J. Am. Chem. Soc. 2012, 134, 15331-15342.

K. Lehr, A. Fürstner
An Efficient Route to the Musk Odorant (R,Z)-5-Muscenone via Base-Metal-Catalysis.
Tetrahedron 2012, 68, 7695-7700.

J. Heppekausen, R. Stade, A. Kondoh, G. Seidel, R. Goddard, A. Fürstner
Optimized Synthesis, Structural Investigations, Ligand Tuning and Synthetic Evaluation of Silyloxy-Based Alkyne Metathesis Catalysts.
Chem.–Eur. J. 2012, 18, 10281-10299.

W. Chaładaj, M. Corbet, A. Fürstner
Total Synthesis of Neurymenolide A Based on a Gold-Catalyzed Synthesis of 4-Hydroxy-2-pyrones.
Angew. Chem., Int. Ed. 2012, 51, 6929-6933.

G. Seidel, A. Fürstner
Suzuki Reactions of Extended Scope: The ‘9-MeO-9-BBN Variant’ as a Complementary Format for Cross-Coupling.
Chem. Commun. (Cambridge, U. K.) 2012, 48, 2055-2070.

2011

K. Lehr, R. Mariz, L. Leseurre, B. Gabor, A. Fürstner
Total Synthesis of Tulearin C.
Angew. Chem., Int. Ed. 2011, 50, 11373-11377.

K. Radkowski, G. Seidel, A. Fürstner
Suzuki-Miyaura Cross Coupling Reactions of B-Allenyl-9-BBN.
Chem. Lett. 2011, 40, 950-952.

S. Benson, M.-P. Collin, A. Arlt, B. Gabor, R. Goddard, A. Fürstner
Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route.
Angew. Chem., Int. Ed. 2011, 50, 8739-8744.

V. Hickmann, A. Kondoh, B. Gabor, M. Alcarazo, A. Fürstner
Catalysis-Based and Protecting-Group-Free Total Syntheses of the Marine Oxylipins Hybridalactone and the Ecklonialactones A, B, and C.
J. Am. Chem. Soc. 2011, 133, 13471-13480.

J. Heppekausen, A. Fürstner
Rendering Schrock-Type Molybdenum Alkylidene Complexes Air Stable: User-Friendly Precatalysts for Alkene Metathesis.
Angew. Chem., Int. Ed. 2011, 50, 7829-7832.

H. Teller, A. Fürstner
Concise Synthesis of the Antidepressive Drug Candidate GSK1360707 by a Highly Enantioselective Gold-Catalyzed Enyne Cycloisomerization Reaction.
Chem.–Eur. J. 2011, 17, 7764-7767.

D. Gallenkamp, A. Fürstner
Stereoselective Synthesis of E,Z-Configured 1,3-Dienes by Ring-Closing Metathesis. Application to the Total Synthesis of Lactimidomycin.
J. Am. Chem. Soc. 2011, 133, 9232-9235.

J. Gagnepain, E. Moulin, C. Nevado, M. Waser, A. Maier, G. Kelter, H.-H. Fiebig, A. Fürstner
Molecular Editing and Assessment of the Cytotoxic Properties of Iejimalide and Progeny.
Chem.–Eur. J. 2011, 17, 6973-6984.

J. Gagnepain, E. Moulin, A. Fürstner
Gram-Scale Synthesis of Iejimalide B.
Chem.–Eur. J. 2011, 17, 6964-6972.

A. Fürstner
Metathesis in Total Synthesis.
Chem. Commun. (Cambridge, U. K.) 2011, 47, 6505-6511.

A. Fürstner
From Total Synthesis to Diverted Total Synthesis: Case Studies in the Amphidinolide Series.
Isr. J. Chem. 2011, 51, 329-345.

M. Alcarazo, K. Radkowski, R. Goddard, A. Fürstner
Metal Complexes with Carbene Ligands Stabilized by Lateral Enamines.
Chem. Commun. (Cambridge, U. K.) 2011, 47, 776-778.

A. Larivée, J. B. Unger, M. Thomas, C. Wirtz, C. Dubost, S. Handa, A. Fürstner
The Leiodolide B Puzzle.
Angew. Chem., Int. Ed. 2011, 50, 304-309.

2010

G. Seidel, C. W. Lehmann, A. Fürstner
Elementary Steps in Gold Catalysis: The Significance of gem-Diauration.
Angew. Chem., Int. Ed. 2010, 49, 8466-8470.

T. N. Snaddon, P. Buchgraber, S. Schulthoff, C. Wirtz, R. Mynott, A. Fürstner
Total Synthesis of Berkelic Acid.
Chem.–Eur. J. 2010, 16, 12133-12140.

K. Micoine, A. Fürstner
Concise Total Synthesis of the Potent Translation and Cell Migration Inhibitor Lactimidomycin.
J. Am. Chem. Soc. 2010, 132, 14064-14066.

M. Alcarazo, R. M. Suárez, R. Goddard, A. Fürstner
A New Class of Singlet Carbene Ligands.
Chem.–Eur. J. 2010, 16, 9746-9749.

J. Heppekausen, R. Stade, R. Goddard, A. Fürstner
Practical New Silyloxy-Based Alkyne Metathesis Catalysts with Optimized Activity and Selectivity Profiles.
J. Am. Chem. Soc. 2010, 132, 11045-11057.

V. Hickmann, M. Alcarazo, A. Fürstner
Protecting-Group-Free and Catalysis-Based Total Synthesis of the Ecklonialactones.
J. Am. Chem. Soc. 2010, 132, 11042-11044.

E. Moulin, C. Nevado, J. Gagnepain, G. Kelter, H.-H. Fiebig, A. Fürstner
Synthesis and Evaluation of an Iejimalide-Archazolid Chimera.
Tetrahedron
2010, 66, 6421-6428.

M. Alcarazo, T. Stork, A. Anoop, W. Thiel, A. Fürstner
Steering the Surprisingly Modular π-Acceptor Properties of N-Heterocyclic Carbenes: Implications for Gold Catalysis.
Angew. Chem., Int. Ed. 2010, 49, 2542-2546.

H. Teller, S. Flügge, R. Goddard, A. Fürstner
Enantioselective Gold Catalysis: Opportunities Provided by Monodentate Phosphoramidite Ligands with an Acyclic TADDOL Backbone.
Angew. Chem., Int. Ed. 2010, 49, 1949-1953.

2009

S. Benson, M.-P. Collin, G. W. O’Neil, J. Ceccon, B. Fasching, M. D. B. Fenster, C. Godbout, K. Radkowski, R. Goddard, A. Fürstner
Total Synthesis of Spirastrellolide F Methyl Ester–Part 2: Macrocyclization and Completion of the Synthesis.
Angew. Chem., Int. Ed. 2009, 48, 9946-9950.

G. W. O’Neil, J. Ceccon, S. Benson, M.-P. Collin, B. Fasching, A. Fürstner
Total Synthesis of Spirastrellolide F Methyl Ester–Part 1: Strategic Considerations and Revised Approach to the Southern Hemisphere.
Angew. Chem., Int. Ed. 2009, 48, 9940-9945.

B. D. Sherry, A. Fürstner
Iron-Catalyzed Addition of Grignard Reagents to Activated Vinyl Cyclopropanes.
Chem. Commun. (Cambridge, U. K.) 2009, 7116-7118.

M. Bindl, L. Jean, J. Herrmann, R. Müller, A. Fürstner
Preparation, Modification, and Evaluation of Cruentaren A and Analogues
Chem.–Eur. J. 2009, 15, 12310-12319.

A. Fürstner
Gold and Platinum Catalysis–A Convenient Tool for Generating Molecular Complexity.
Chem. Soc. Rev. 2009, 38, 3208-3221.

A. Masarwa, A. Fürstner, I. Marek
Metal-Catalyzed Rearrangement of Enantiomerially Pure Alkylidenecyclopropane Derivatives as a New Access to Cyclobutenes Possessing Quaternary Stereocenters.
Chem. Commun. (Cambridge, U. K.) 2009, 5760-5762.

T. Nagano, J. Pospíšil, G. Chollet, S. Schulthoff, V. Hickmann, E. Moulin, J. Herrmann, R. Müller, A. Fürstner
Total Synthesis and Biological Evaluation of the Cytotoxic Resin Glycosides Ipomoeassin A–F and Analogues.
Chem.–Eur. J. 2009, 15, 9697-9706.

A. Fürstner, M. Alcarazo, H. Krause
Tetrakis(dimethylamino)allene.
Org. Synth. 2009, 86, 298-307.

S. Flügge, A. Anoop, R. Goddard, W. Thiel, A. Fürstner
Structure and Bonding in Neutral and Cationic 14-Electron Gold Alkyne π Complexes.
Chem.–Eur. J. 2009, 15, 8558-8565.

P. Buchgraber, M. M. Domostoj, B. Scheiper, C. Wirtz, R. Mynott, J. Rust, A. Fürstner
Synthesis-Driven Mapping of the Dictyodendrin Alkaloids.
Tetrahedron 2009, 65, 6519-6534.

M. Bindl, R. Stade, E. K. Heilmann, A. Picot, R. Goddard, A. Fürstner
Molybdenum Nitride Complexes with Ph3SiO Ligands are Exceedingly Practical and Tolerant Precatalysts for Alkyne Metathesis and Efficient Nitrogen Transfer Agents.
J. Am. Chem. Soc. 2009, 131, 9468-9470.

M. Alcarazo, C. W. Lehmann, A. Anoop, W. Thiel, A. Fürstner
Coordination Chemistry at Carbon.
Nat. Chem. 2009, 1, 295-301.

J. Pospíšil, C. Müller, A. Fürstner
Total Synthesis of the Aspercyclides.
Chem.–Eur. J. 2009, 15, 5956-5968.

A. Fürstner, E. Kattnig, G. Kelter, H.-H. Fiebig
Molecular Editing and Biological Evaluation of Amphidinolide X and Y.
Chem.–Eur. J. 2009, 15, 4030-4043.

A. Fürstner, S. Flügge, O. Larionov, Y. Takahashi, T. Kubota, J. Kobayashi
Total Synthesis and Biological Evaluation of Amphidinolide V and Analogues.
Chem.–Eur. J. 2009, 15, 4011-4029.

A. Fürstner, L. C. Bouchez, L. Morency, J.-A. Funel, V. Liepins, F.-H. Porée, R. Gilmour, D. Laurich, F. Beaufils, M. Tamiya
Total Syntheses of Amphidinolides B1, B4, G1, H1 and Structure Revision of Amphidinolide H2.
Chem.–Eur. J. 2009, 15, 3983-4010.

G. Seidel, R. Mynott, A. Fürstner
Elementary Steps of Gold Catalysis: NMR Spectroscopy Reveals the Highly Cationic Character of a “Gold Carbenoid”.
Angew. Chem., Int. Ed. 2009, 48, 2510-2513.

A. Fürstner
From Oblivion into the Limelight: Iron (Domino) Catalysis.
Angew. Chem., Int. Ed. 2009, 48, 1364-1367.

2008

B. D. Sherry, A. Fürstner
The Promise and Challenge of Iron-Catalyzed Cross Coupling.
Acc. Chem. Res. 2008, 41, 1500-1511.

A. Fürstner, A. Schlecker
A Gold-Catalyzed Entry into the Sesquisabinene and Sesquithujene Families of Terpenoids and Formal Total Syntheses of Cedrene and Cedrol.
Chem.–Eur. J. 2008, 14, 9181-9191.

P. Buchgraber, T. N. Snaddon, C. Wirtz, R. Mynott, R. Goddard, A. Fürstner
A Synthesis-Driven Structure Revision of Berkelic Acid Methyl Ester.
Angew. Chem., Int. Ed. 2008, 47, 8450-8454.

A. Fürstner, M. Alcarazo, K. Radkowski, C. W. Lehmann
Carbenes Stabilized by Ylides: Pushing the Limits.
Angew. Chem., Int. Ed. 2008, 47, 8302-8306.

G. W. O’Neil, A. Fürstner
B-Alkyl Suzuki Couplings for the Stereoselective Synthesis of Substituted Pyrans.
Chem. Commun. (Cambridge, U. K.) 2008, 4294-4296.

A. Fürstner, R. Martin, H. Krause, G. Seidel, R. Goddard, C. W. Lehmann
Preparation, Structure, and Reactivity of Nonstabilized Organoiron Compounds. Implications for Iron-Catalyzed Cross Coupling Reactions.
J. Am. Chem. Soc. 2008, 130, 8773-8787.

A. Fürstner, J.-A. Funel, M. Tremblay, L. C. Bouchez, C. Nevado, M. Waser, J. Ackerstaff, C. C. Stimson
A Versatile Protocol for Stille-Migita Cross Coupling Reactions.
Chem. Commun. (Cambridge, U. K.) 2008, 2873-2875.

A. Fürstner, J. Ackerstaff
Formal Total Synthesis of (−)-Haouamine A.
Chem. Commun. (Cambridge, U. K.) 2008, 2870-2872.

A. Fürstner, L. Morency
On the Nature of the Reactive Intermediates in Gold-Catalyzed Cycloisomerization Reactions.
Angew. Chem., Int. Ed. 2008, 47, 5030-5033.

A. Fürstner, M. Alcarazo, R. Goddard, C. W. Lehmann
Coordination Chemistry of Ene-1,1-diamines and a Prototype “Carbodicarbene”.
Angew. Chem., Int. Ed. 2008, 47, 3210-3214.

A. Fürstner, K. Majima, R. Martín, H. Krause, E. Kattnig, R. Goddard, C. W. Lehmann
A Cheap Metal for a “Noble” Task: Preparative and Mechanistic Aspects of Cycloisomerization and Cycloaddition Reactions Catalyzed by Low-Valent Iron Complexes.
J. Am. Chem. Soc. 2008, 130, 1992-2004.

A. Fürstner, A. Korte
Total Synthesis of Epohelmin B and its Analogues.
Chem.–Asian J. 2008, 3, 310-318.

W. Gao, A. P.-C. Chen, C.-H. Leung, E. A. Gullen, A. Fürstner, Q. Shi, L. Wei, K.-H. Lee, Y. C. Cheng
Structural Analogs of Tylophora Alkaloids may not be Functional Analogs.
Bioorg. Med. Chem. Lett. 2008, 18, 704-709.

A. Fürstner, M. Alcarazo, V. César, H. Krause
Preparation of a Non-Symmetrical Imidazolium Salt: 1-Adamantyl-3-mesityl-4,5-dimethylimidazolium Tetrafluoroborate
Org. Synth. 2008, 85, 34-44.

2007

A. Fürstner, M. Bindl, L. Jean
Concise Total Synthesis of Cruentaren A.
Angew. Chem., Int. Ed. 2007, 46, 9275-9278.

A. Fürstner, L. C. Bouchez, J.-A. Funel, V. Liepins, F.-H. Porée, R. Gilmour, F. Beaufils, D. Laurich, M. Tamiya
Total Syntheses of Amphidinolide H and G.
Angew. Chem., Int. Ed. 2007, 46, 9265-9270.

C. Aïssa, A. Fürstner
A Rhodium-Catalyzed C-H Activation/Cycloisomerization Tandem.
J. Am. Chem. Soc. 2007, 129, 14836-14837.

A. Fürstner, C. C. Stimson
Two Manifolds for Metal-Catalyzed Intramolecular Diels-Alder Reactions of Unactivated Alkynes.
Angew. Chem., Int. Ed. 2007, 46, 8845-8849.

A. Fürstner, M. Alcarazo, H. Krause, C. W. Lehmann
Effective Modulation of the Donor Properties of N-Heterocyclic Carbene Ligands by
“Through-Space” Communication within a Planar Chiral Scaffold.
J. Am. Chem. Soc. 2007, 129, 12676-12677.

A. Fürstner, M. Bonnekessel, J. T. Blank, K. Radkowski, G. Seidel, F. Lacombe, B. Gabor,
R. Mynott
Total Synthesis of Myxovirescin A1.
Chem.–Eur. J. 2007, 13, 8762-8783.

A. Fürstner, A. Schlecker, C. W. Lehmann
Facile Formation of Iodocyclobutenes by a Ruthenium-Catalyzed Enyne Cycloisomerization.
Chem. Commun. (Cambridge, U. K.) 2007, 4277-4279.

G. Occhipinti, H.-R. Bjørsvik, K. W. Törnroos, A. Fürstner, V. R. Jensen
The First Imidazolium-Substituted Metal Alkylidene.
Organometallics 2007, 26, 4383-4385.

A. Fürstner, B. Fasching, G. W. O’Neil, M. D. B. Fenster, C. Godbout, J. Ceccon,
Toward the Total Synthesis of Spirastrellolide A. Part 3: Intelligence Gathering and Preparation of a Ring-Expanded Analogue.
Chem. Commun. (Cambridge, U. K.) 2007, 3045-3047.

A. Fürstner, C. Nevado, M. Waser, M. Tremblay, C. Chevrier, F. Teplý, C. Aïssa, E. Moulin,
O. Müller
Total Synthesis of Iejimalide A-D and Assessment of the Remarkable Actin-Depolymerizing Capacity of these Polyene Macrolides.
J. Am. Chem. Soc. 2007, 129, 9150-9161.

A. Fürstner, O. Larionov, S. Flügge
What is Amphidinolide V? Report on a Likely Conquest.
Angew. Chem., Int. Ed. 2007, 46, 5545-5548.

A. Fürstner, E. K. Heilmann, P. W. Davies
Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl2-Catalyzed Cycloisomerization Reaction.
Angew. Chem., Int. Ed. 2007, 46, 4760-4763.

A. Fürstner, P. W. Davies
Catalytic Carbophilic Activation: Catalysis by Platinum and Gold π Acids.
Angew. Chem., Int. Ed. 2007, 46, 3410-3449.

A. Fürstner, K. Radkowski, H. Peters, G. Seidel, C. Wirtz, R. Mynott, C. W. Lehmann
Total Synthesis, Molecular Editing and Evaluation of a Tripyrrolic Natural Product: The Case of “Butylcycloheptylprodigiosin”.
Chem.–Eur. J. 2007, 13, 1929-1945.

A. Fürstner, T. Nagano
Total Syntheses of Ipomoeassin B and E.
J. Am. Chem. Soc. 2007, 129, 1906-1907.

A. Fürstner
Case Studies at the Metathesis/Asymmetric Synthesis Interface.
In: Asymmetric Synthesis – The Essentials (M. Christmann, S. Bräse, Eds.), Wiley-VCH, Weinheim, 2007, pp. 262-266.

A. Fürstner, T. Nagano, C. Müller, G. Seidel, O. Müller
Total Synthesis and Evaluation of the Actin-Binding Properties of Microcarpalide and a Focused Library of Analogues.
Chem.–Eur. J. 2007, 13, 1452-1462.

A. Fürstner, D. Kirk, M. D. B. Fenster, C. Aïssa, D. De Souza, C. Nevado, T. Tuttle,
W. Thiel, O. Müller
Latrunculin Analogues with Improved Biological Profiles by “Diverted Total Synthesis”: Preparation, Evaluation, and Computational Analysis.
Chem.–Eur. J. 2007, 13, 135-149.

A. Fürstner, D. De Souza, L. Turet, M. D. B. Fenster, L. Parra-Rapado, C. Wirtz, R. Mynott,
C. W. Lehmann
Total Syntheses of the Actin-Binding Macrolides Latrunculin A, B, C, M, S and 16-epi-Lactrunculin B.
Chem.–Eur. J. 2007, 13, 115-134.

2006

A. Fürstner, V. Mamane, G. Seidel, D. Laurich
Indium-Catalyzed Cycloisomerization: Preparation of 4-Methylpyrrolo[1,2-a]quinoline.
Org. Synth. 2006, 83, 103-110.

A. Fürstner, J. W. J. Kennedy
Total Syntheses of the Tylophora Alkaloids Cryptopleurine, (−)-Antofine, (−)-Tylophorine, and (−)-Ficuseptine C.
Chem.–Eur. J. 2006, 12, 7398-7410.

A. Fürstner, C. Nevado, M. Tremblay, C. Chevrier, F. Teplý, C. Aïssa, M. Waser
Total Synthesis of Iejimalide B.
Angew. Chem., Int. Ed. 2006, 45, 5837-5842.

A. Fürstner, C. Aïssa, C. Chevrier, F. Teplý, C. Nevado, M. Tremblay
Studies on Iejimalide B: Preparation of the Seco Acid and Identification of the Molecule’s
“Achilles Heel”.
Angew. Chem., Int. Ed. 2006, 45, 5832-5837.

A. Fürstner, M. D. B. Fenster, B. Fasching, C. Godbout, K. Radkowski
Toward the Total Synthesis of Spirastrellolide A. Part 2: Conquest of the Northern Hemisphere.
Angew. Chem., Int. Ed. 2006, 45, 5510-5515.

A. Fürstner, M. D. B. Fenster, B. Fasching, C. Godbout, K. Radkowski
Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain.
Angew. Chem., Int. Ed. 2006, 45, 5506-5510.

A. Fürstner, E. Kattnig, O. Lepage
Total Syntheses of Amphidinolide X and Y.
J. Am. Chem. Soc. 2006, 128, 9194-9204.

A. Fürstner, M. M. Domostoj, B. Scheiper
Total Syntheses of the Telomerase Inhibitors Dictyodendrin B, C, and E.
J. Am. Chem. Soc. 2006, 128, 8087-8094.

A. Fürstner, C. Aïssa
PtCl2-Catalyzed Rearrangement of Methylenecyclopropanes.
J. Am. Chem. Soc. 2006, 128, 6306-6307.

A. Fürstner, M. Alcarazo, V. César, C. W. Lehmann
Convenient, Scalable and Flexible Method for the Preparation of Imidazolium Salts with Previously Inaccessible Substitution Patterns.
Chem. Commun. (Cambridge, U. K.) 2006, 2176-2178.

A. Fürstner, P. Hannen
Platinum- and Gold-Catalyzed Rearrangement Reactions of Propargyl Acetates: Total Syntheses of (−)-α-Cubebene, (−)-Cubebol, Sesquicarene and Related Terpenes.
Chem.–Eur. J. 2006, 12, 3006-3019.

A. Fürstner, H. Krause, C. W. Lehmann
Unusual Structure and Reactivity of a Homoleptic “Super-Ate” Complex of Iron: Implications for Grignard Additions, Cross-Coupling Reactions, and the Kharasch Deconjugation.
Angew. Chem., Int. Ed. 2006, 45, 440-444.

A. Fürstner, M. Wuchrer
Concise Approach to the  Higher Sugar  Core of the Nucleoside Antibiotic Hikizimycin.
Chem.–Eur. J. 2006, 12, 76-89.

2005

A. Fürstner, C. Müller
Total Synthesis of Aspercyclide C.
Chem. Commun. (Cambridge, U. K.) 2005, 5583-5585.

A. Fürstner, P. W. Davies
Heterocycles by PtCl2-Catalyzed Intramolecular Carboalkoxylation or Carboamination of Alkynes.
J. Am. Chem. Soc. 2005, 127, 15024-15025.

S. Abuhamdah, A. Fürstner, G. Lees, P. L. Chazot
Radioligand Binding Studies of Caloporoside and Novel Congeners with Contrasting Effects upon [35S] TBPS Binding to the Mammalian GABAA Receptor.
Biochem. Pharmacol. 2005, 70, 1382-1388.

M. BeÅŸev, C. Brehm, A. Fürstner
Formal Total Syntheses of Crocacin A-D.
Collect. Czech. Chem. Commun. 2005, 70, 1696-1708.

M. Manger, M. Scheck, H. Prinz, J. P. von Kries, T. Langer, K. Saxena, H. Schwalbe,
A. Fürstner, J. Rademann, H. Waldmann
Discovery of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase A (MptpA) Inhibitors Based on Natural Products and Fragment-Based Approach.
ChemBioChem 2005, 6, 1749-1753.

A. Fürstner, R. Martín, K. Majima
Cycloisomerization of Enynes Catalyzed by Iron(0)–Ate Complexes.
J. Am. Chem. Soc. 2005, 127, 12236-12237.

A. Fürstner, M. M. Domostoj, B. Scheiper
Total Synthesis of Dictyodendrin B.
J. Am. Chem. Soc. 2005, 127, 11620-11621.

A. Fürstner, P. W. Davies, C. W. Lehmann
Bidentate Ruthenium Vinylcarbene Catalysts Derived from Enyne Metathesis.
Organometallics 2005, 24, 4065-4071.

N. Ghalit, A. J. Poot, A. Fürstner, D. T. S. Rijkers, R. M. J. Liskamp
Ring-Closing Alkyne Metathesis Approach toward the Synthesis of Alkyne Mimics of Thioether A-, B-, C-, and DE-Ring Systems of the Lantibiotic Nisin Z.
Org. Lett. 2005, 7, 2961-2964.

A. Fürstner, P. W. Davies, T. Gress
Cyclobutenes by Platinum-Catalyzed Cycloisomerization Reactions of Enynes.
J. Am. Chem. Soc. 2005, 127, 8244-8245.

A. Fürstner, D. Kirk, M. D. B. Fenster, C. Aïssa, D. De Souza, O. Müller
Diverted Total Synthesis: Preparation of a Focused Library of Latrunculin Analogues and Evaluation of Their Actin-Binding Properties.
Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 8103-8108.

A. Fürstner, L. Turet
Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne-Yne Metathesis.
Angew. Chem., Int. Ed. 2005, 44, 3462-3466.

A. Fürstner, P. W. Davies
Alkyne Metathesis.
Chem. Commun. (Cambridge, U. K.) 2005, 2307-2320.

A. Fürstner, K. Radkowski, H. Peters
Chasing a Phantom by Total Synthesis: The Butylcycloheptylprodigiosin Case.
Angew. Chem., Int. Ed. 2005, 44, 2777-2781.

A. Fürstner, R. Martin
Advances in Iron Catalyzed Cross Coupling Reactions.
Chem. Lett. 2005, 34, 624-629.

D. Kremzow, G. Seidel, C. W. Lehmann, A. Fürstner
Diaminocarbene- and Fischer-Carbene Complexes of Palladium and Nickel by Oxidative Insertion: Preparation, Structure, and Catalytic Activity.
Chem.–Eur. J. 2005, 11, 1833-1853.

M. Mayr, D. Wang, R. Kröll, N. Schuler, S. Prühs, A. Fürstner, M. R. Buchmeiser
Monolithic Disk-Supported Metathesis Catalysts for Use in Combinatorial Chemistry.
Adv. Synth. Catal. 2005, 347, 484-492.

A. Fürstner
Reflections upon Olefin Metathesis in Carbohydrate Chemistry.
In: Glycomimetics: Modern Synthetic Methodologies (R. Roy, Ed.), ACS Symp. Ser., Vol. 896, American Chemical Society, Washington, 2005, pp. 1-22.

A. Fürstner, A. Leitner, G. Seidel
4-Nonylbenzoic Acid.
Org. Synth. 2005, 81, 33-42.

2004

O. Lepage, E. Kattnig, A. Fürstner
Total Synthesis of Amphidinolide X.
J. Am. Chem. Soc. 2004, 126, 15970-15971.

A. Fürstner, P. Hannen
Carene Terpenoids by Gold-Catalyzed Cycloisomerization Reactions.
Chem. Commun. (Cambridge, U. K.) 2004, 2546-2547.

A. Fürstner, K. Reinecke, H. Prinz, H. Waldmann
The Core Structures of Roseophilin and the Prodigiosin Alkaloids Define a New Class of Protein Tyrosine Phosphatase Inhibitors.
ChemBioChem 2004, 5, 1575-1579.

A. Fürstner, F. Feyen, H. Prinz, H. Waldmann
Synthesis and Evaluation of the Antitumor Agent TMC-69-6H and a Focused Library of Analogs.
Tetrahedron 2004, 60, 9543-9558.

V. Mamane, P. Hannen, A. Fürstner
Synthesis of Phenanthrenes and Polycyclic Heteroarenes by Transition-Metal Catalyzed Cycloisomerization Reactions.
Chem.–Eur. J. 2004, 10, 4556-4575.

B. Scheiper, F. Glorius, A. Leitner, A. Fürstner
Catalysis-Based Enantioselective Total Synthesis of the Macrocyclic Spermidine Alkaloid Isooncinotine.
Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 11960-11965.

F. Lacombe, K. Radkowski, G. Seidel, A. Fürstner
(E)-Cycloalkenes and (E,E)-Cycloalkadienes by Ring Closing Diyne- or Enyne-yne Metathesis/Semi-Reduction.
Tetrahedron 2004, 60, 7315-7324.

R. Martin, A. Fürstner
Cross-Coupling of Alkyl Halides with Aryl Grignard Reagents Catalyzed by a Low-Valent
Iron Complex.
Angew. Chem., Int. Ed. 2004, 43, 3955-3957.

V. Mamane, T. Gress, H. Krause, A. Fürstner
Platinum- and Gold-Catalyzed Cycloisomerization Reactions of Hydroxylated Enynes.
J. Am. Chem. Soc. 2004, 126, 8654-8655.

G. Seidel, D. Laurich, A. Fürstner
Iron-Catalyzed Cross-Coupling Reactions. A Scalable Synthesis of the Immunosuppressive
Agent FTY720.
J. Org. Chem. 2004, 69, 3950-3952.

B. Scheiper, M. Bonnekessel, H. Krause, A. Fürstner
Selective Iron-Catalyzed Cross-Coupling Reactions of Grignard Reagents with Enol Triflates, Acid Chlorides, and Dichloroarenes.
J. Org. Chem. 2004, 69, 3943-3949.

J. Mlynarski, J. Ruiz-Caro, A. Fürstner
Total Synthesis of Macroviracin D (BA-2836-4).
Chem.–Eur. J. 2004, 10, 2214-2222.

A. Fürstner
Total Syntheses and Biological Assessment of Macrocyclic Glycolipids.
Eur. J. Org. Chem. 2004, 943-958.

S. Prühs, C. W. Lehmann, A. Fürstner
Preparation, Reactivity, and Structural Peculiarities of Hydroxyalkyl-Functionalized “Second Generation” Ruthenium Carbene Complexes.
Organometallics 2004, 23, 280-287.

A. Fürstner, J. Ruiz-Caro, H. Prinz, H. Waldmann
Structure Assignment, Total Synthesis, and Evaluation of the Phosphatase Modulating Activity of Glucolipsin A.
J. Org. Chem. 2004, 69, 459-467.

2003

C. Aïssa, R. Riveiros, J. Ragot, A. Fürstner
Total Syntheses of Amphidinolide T1, T3, T4, and T5.
J. Am. Chem. Soc. 2003, 125, 15512-15520.

A. Fürstner, F. Feyen, H. Prinz, H. Waldmann
Total Synthesis and Reassessment of the Phosphatase-Inhibitory Activity of the Antitumor Agent TMC-69-6H.
Angew. Chem., Int. Ed. 2003, 42, 5361-5364.

A. Fürstner, D. De Souza, L. Parra-Rapado, J. T. Jensen
Catalysis-Based Total Synthesis of Latrunculin B.
Angew. Chem., Int. Ed. 2003, 42, 5358-5360.

A. Fürstner, M. Méndez
Iron-Catalyzed Cross-Coupling Reactions: Efficient Synthesis of 2,3-Allenol Derivatives.
Angew. Chem., Int. Ed. 2003, 42, 5355-5357.

A. Fürstner, M. Albert, J. Mlynarski, M. Matheu, E. DeClercq
Structure Assignment, Total Synthesis, and Antiviral Evaluation of Cycloviracin B1.
J. Am. Chem. Soc. 2003, 125, 13132-13142.

A. Fürstner
Alkyne Metathesis.
In: Handbook of Metathesis, Vol. 2: Application in Organic Synthesis (R. H. Grubbs, Ed.),
Wiley-VCH, Weinheim, 2003, pp. 432-462.

A. Fürstner, V. Mamane
Concise Total Synthesis of the Aporphine Alkaloid 7,7’-Bisdehydro-O-methylisopiline by an
InCl3 Mediated Cycloisomerization Reaction.
Chem. Commun. (Cambridge, U. K.) 2003, 2112-2113.

D. Song, G. Blond, A. Fürstner
Study Towards Bioactive Pyrone Derivatives from the Marine Red Alga Phacelocarpus labillardieri.
Tetrahedron 2003, 59, 6899-6904.

A. Fürstner
Chemistry and Biology of Roseophilin and the Prodigiosin Alkaloids: A Survey of the Last
2500 Years.
Angew. Chem., Int. Ed. 2003, 42, 3582-3603.

M. Méndez, V. Mamane, A. Fürstner
Platinum-Catalyzed Skeletal Rearrangement Reactions: Generating Structural Diversity by a Uniform Mechanism.
Chemtracts 2003, 16, 397-425.

A. Fürstner, G. Seidel, D. Kremzow, C. W. Lehmann
Preparation of Metal-Imidazolidin-2-ylidene Complexes by Oxidative Addition.
Organometallics 2003, 22, 907-909.

A. Fürstner, A.-S. Castanet, K. Radkowski, C. W. Lehmann
Total Synthesis of (S)-(+)-Citreofuran by Ring Closing Alkyne Metathesis.
J. Org. Chem. 2003, 68, 1521-1528.

A. Fürstner, A. Leitner
A Catalytic Approach to (R)-(+)-Muscopyridine with Integrated “Self-clearance”.
Angew. Chem., Int. Ed. 2003, 42, 308-311.

A. Fürstner, F. Jeanjean, P. Razon, C. Wirtz, R. Mynott
Total Synthesis of Woodrosin I—Part 2: Final Stages Involving RCM and an Orthoester Rearrangement.
Chem.–Eur. J. 2003, 9, 320-326.

A. Fürstner, F. Jeanjean, P. Razon, C. Wirtz, R. Mynott
Total Synthesis of Woodrosin I—Part 1: Preparation of the Building Blocks and Evaluation
of the Glycosylation Strategy.
Chem.–Eur. J. 2003, 9, 307-319.

2002

A. Fürstner, C. Aïssa, R. Riveiros, J. Ragot
Total Synthesis of Amphidinolide T4.
Angew. Chem., Int. Ed. 2002, 41, 4763-4766.

A. Fürstner, A. Leitner, M. Méndez, H. Krause
Iron-Catalyzed Cross-Coupling Reactions.
J. Am. Chem. Soc. 2002, 124, 13856-13863.

A. Fürstner, J. Mlynarski, M. Albert
Total Synthesis of the Antiviral Glycolipid Cycloviracin B1.
J. Am. Chem. Soc. 2002, 124, 10274-10275.

A. Fürstner, K. Radkowski
A Chemo- and Stereoselective Reduction of Cycloalkynes to (E)-Cycloalkenes.
Chem. Commun. (Cambridge, U. K.) 2002, 2182-2183.

A. Fürstner, V. Mamane
Flexible Synthesis of Phenanthrenes by a PtCl2-Catalyzed Cycloisomerization Reaction.
J. Org. Chem. 2002, 67, 6264-6267.

A. Fürstner, M. Schlede
Formal Total Synthesis of Ascidiatrienolide A and the Didemnilactones.
Adv. Synth. Catal. 2002, 344, 657-665.

A. Fürstner, H. Krause, O. R. Thiel
Efficient Relay Syntheses and Assessment of the DNA-Cleaving Properties of the Pyrrole Alkaloid Derivatives Permethyl Storniamide A, Lycogalic Acid A Dimethyl Ester, and the Halitulin Core.
Tetrahedron 2002, 58, 6373-6380.

A. Fürstner, K. Radkowski, C. Wirtz, R. Goddard, C. W. Lehmann, R. Mynott
Total Syntheses of the Phytotoxic Lactones Herbarumin I and II and a Synthesis-Based
Solution of the Pinolidoxin Puzzle.
J. Am. Chem. Soc. 2002, 124, 7061-7069.

A. Fürstner, F. Jeanjean, P. Razon
Total Synthesis of Woodrosin I.
Angew. Chem., Int. Ed. 2002, 41, 2097-2101.

A. Fürstner, F. Stelzer, A. Rumbo, H. Krause
Total Synthesis of the Turrianes and Evaluation of their DNA-Cleaving Properties.
Chem.–Eur. J. 2002, 8, 1856-1871.

A. Fürstner, G. Seidel
Microwave-Assisted Synthesis of Pinacol Boronates from Aryl Chlorides Catalyzed by a Palladium/Imidazolium Salt System.
Org. Lett. 2002, 4, 541-543.

S. Pandey, M. A. Kane, G. A. Baker, F. V. Bright, A. Fürstner, G. Seidel, W. Leitner
The Photophysics of 6-(1-Pyrenyl)hexyl-11(1-pyrenyl)undecanoate Dissolved in Organic Liquids and Supercritical Carbon Dioxide: Impact on Olefin Metathesis.
J. Phys. Chem. B 2002, 106, 1820-1832.

A. Fürstner, M. Albert, J. Mlynarski, M. Matheu
A Concise Synthesis of the Fully Functional Lactide Core of Cycloviracin B with Implications for the Structural Assignment of Related Glycolipids.
J. Am. Chem. Soc. 2002, 124, 1168-1169.

A. Fürstner, A. Leitner
Iron-Catalyzed Cross-Coupling Reactions of Alkyl-Grignard Reagents with Aryl Chlorides, Tosylates, and Triflates.
Angew. Chem., Int. Ed. 2002, 41, 609-612.

A. Fürstner, O. R. Thiel, C. W. Lehmann
Study Concerning the Effects of Chelation on the Structure and Catalytic Activity of Ruthenium Carbene Complexes.
Organometallics 2002, 21, 331-335.

2001

A. Fürstner, C. Mathes, C. W. Lehmann
Alkyne Metathesis: Development of a Novel Molybdenum-Based Catalyst System and Its Application to the Total Synthesis of Epothilone A and C.
Chem.–Eur. J. 2001, 7, 5299-5317.

A. Fürstner, T. Dierkes, O. R. Thiel, G. Blanda
Total Synthesis of (−)-Salicylihalamide.
Chem.–Eur. J. 2001, 7, 5286-5298.

A. Fürstner, F. Stelzer, H. Szillat
Platinum-Catalyzed Cycloisomerization Reactions of Enynes.
J. Am. Chem. Soc. 2001, 123, 11863-11869.

A. Fürstner, C. Brehm, Y. Cancho-Grande
Stereoselective Synthesis of Enamides by a Peterson Reaction Manifold.
Org. Lett. 2001, 3, 3955-3957.

A. Fürstner, H. Krause, C. W. Lehmann
Preparation, Structure and Catalytic Properties of a Binuclear Pd(0) Complex with
Bridging Silylene Ligands.
Chem. Commun. (Cambridge, U. K.) 2001, 2372-2373.

A. Fürstner, O. Guth, A. Düffels, G. Seidel, M. Liebl, B. Gabor, R. Mynott
Indenylidene Complexes of Ruthenium: Optimized Synthesis, Structure Elucidation,
and Performance as Catalysts for Olefin Metathesis―Application to the Synthesis
of the ADE-Ring System of Nakadomarin A.
Chem.–Eur. J. 2001, 7, 4811-4820.

A. Fürstner, H. Krause, L. Ackermann, C. W. Lehmann
N-Heterocyclic Carbenes Can Coexist with Alkenes and C-H Acidic Sites.
Chem. Commun. (Cambridge, U. K.) 2001, 2240-2241.

A. Fürstner, L. Ackermann, K. Beck, H. Hori, D. Koch, K. Langemann, M. Liebl, C. Six, W. Leitner
Olefin Metathesis in Supercritical Carbon Dioxide.
J. Am. Chem. Soc. 2001, 123, 9000-9006.

A. Fürstner, E. J. Grabowski
Studies on DNA Cleavage by Cytotoxic Pyrrole Alkaloids Reveal the Distinctly Different Behavior of Roseophilin and Prodigiosin Derivatives.
ChemBioChem 2001, 2, 706-709.

A. Fürstner, L. Ackermann, B. Gabor, R. Goddard, C. W. Lehmann, R. Mynott, F. Stelzer,
O. R. Thiel
Comparative Investigation of Ruthenium-Based Metathesis Catalysts Bearing N-Heterocyclic Carbene (NHC) Ligands.
Chem.–Eur. J. 2001, 7, 3236-3253.


A. Fürstner, C. Mathes, K. Grela
Concise Total Syntheses of Epothilone A and C Based on Alkyne Metathesis.
Chem. Commun. (Cambridge, U. K.) 2001, 1057-1059.

A. Fürstner, H. Krause
Practical Method for the Rhodium-Catalyzed Addition of Aryl- and Alkenylboronic Acids
to Aldehydes.
Adv. Synth. Catal. 2001, 343, 343-350.

B. Aguilera, L. B. Wolf, P. Nieczypor, F. P. J. T. Rutjes, H. S. Overkleeft, J. C. M. van Hest,
H. E. Schoemaker, B. Wang, J. C. Mol, A. Fürstner, M. Overhand, G. A. van der Marel,
J. H. van Boom
Synthesis of Diaminosuberic Acid Derivatives via Ring-Closing Alkyne Metathesis.
J. Org. Chem. 2001, 66, 3584-3589.

A. Fürstner, K. Radkowski
Enantioselective Total Synthesis of the Phytotoxic Lactone Herbarumin I.
Chem. Commun. (Cambridge, U. K.) 2001, 671-672.

A. Fürstner, A. Leitner
General and User-Friendly Methods for Suzuki Reactions with Aryl Chlorides.
Synlett 2001, 290-292.

A. Fürstner, O. R. Thiel, L. Ackermann
Exploiting the Reversibility of Olefin Metathesis. Syntheses of Macrocyclic Trisubstituted Alkenes and (R,R)-(−)-Pyrenophorin.
Org. Lett. 2001, 3, 449-451.

A. Fürstner, D. Voigtländer, W. Schrader, D. Giebel, M. T. Reetz
A "Hard/Soft" Mismatch Enables Catalytic Friedel-Crafts Acylations.
Org. Lett. 2001, 3, 417-420.

A. Fürstner, C. Mathes
Alkyne Cross Metathesis Reactions of Extended Scope.
Org. Lett. 2001, 3, 221-223.

A. Fürstner, J. Grabowski, C. W. Lehmann, T. Kataoka, K. Nagai
Synthesis and Biological Evaluation of Nonylprodigiosin and Macrocyclic Prodigiosin Analogues.
ChemBioChem 2001, 2, 60-68.

2000

A. Fürstner, O. R. Thiel, G. Blanda
Asymmetric Synthesis of the Fully Functional Macrolide Core of Salicylihalamide:
Remote Control of Olefin Geometry during RCM.
Org. Lett. 2000, 2, 3731-3734.

A. Fürstner, K. Radkowski, J. Grabowski, C. Wirtz, R. Mynott
Ring-Closing Alkyne Metathesis. Application to the Total Synthesis of Sophorolipid Lactone.
J. Org. Chem. 2000, 65, 8758-8762.

A. Fürstner, K. Grela, C. Mathes, C. W. Lehmann
Novel and Flexible Entries into Prostaglandins and Analogues Based on Ring Closing Alkyne Metathesis or Alkyne Cross Metathesis.
J. Am. Chem. Soc. 2000, 122, 11799-11805.

A. Fürstner, O. R. Thiel, N. Kindler, B. Bartkowska
Total Syntheses of (S)-(−)-Zearalenone and Lasiodiplodin Reveal Superior Metathesis Activity
of Ruthenium Carbene Complexes with Imidazol-2-ylidine Ligands.
J. Org. Chem. 2000, 65, 7990-7995.

A. Fürstner, T. Gastner
Total Synthesis of Cristatic Acid.
Org. Lett. 2000, 2, 2467-2470.

A. Fürstner, T. Dierkes
Concise Synthesis of (S,S)-(+)-Dehydrohomoancepsenolide.
Org. Lett. 2000, 2, 2463-2465.

A. Fürstner
Olefin Metathesis and Beyond.
Angew. Chem., Int. Ed. 2000, 39, 3012-3043.

A. Fürstner, D. Voigtländer
"Halophilic Activation" of Chlorosilanes: Allylation of Aldehydes Catalyzed by Platinum Chloride
or Silver Triflate.
Synthesis 2000, 959-969.

A. Fürstner, A. Rumbo
Ring-Closing Alkyne Metathesis. Stereoselective Synthesis of the Cytotoxic Marine Alkaloid Motuporamine C.
J. Org. Chem. 2000, 65, 2608-2611.

A. Fürstner, H. Szillat, F. Stelzer
Novel Rearrangements of Enynes Catalyzed by PtCl2.
J. Am. Chem. Soc. 2000, 122, 6785-6786.

A. Fürstner, G. Seidel
Ring Closing Alkyne Metathesis. Stereoselective Synthesis of Civetone.
J. Organomet. Chem. 2000, 606, 75-78.

A. Fürstner, O. R. Thiel, L. Ackermann, H.-J. Schanz, S. P. Nolan
Ruthenium Carbene Complexes with N,N'-Bis(mesityl)imidazol-2-ylidine Ligands: RCM Catalysts of Extended Scope.
J. Org. Chem. 2000, 65, 2204-2207.

M. T. Reetz, M. H. Becker, M. Liebl, A. Fürstner
IR-Thermographic Screening of Thermoneutral or Endothermic Transformations: The Ring-Closing Olefin Metathesis Reaction.
Angew. Chem., Int. Ed. 2000, 39, 1236-1239.

A. Fürstner, K. Grela
Ring Closing Alkyne Metathesis. Application to the Stereoselective Total Synthesis of Prostaglandin E2-1,15 Lactone.
Angew. Chem., Int. Ed. 2000, 39, 1234-1236.

A. Fürstner, M. Liebl, C. W. Lehmann, M. Picquet, R. Kunz, C. Bruneau, D. Touchard, P. H. Dixneuf
Cationic Ruthenium Allenylidene Complexes as Catalysts for Ring Closing Olefin Metathesis.
Chem.–Eur. J. 2000, 6, 1847-1857.

A. Fürstner, O. R. Thiel
Formal Total Synthesis of (−)-Balanol: Concise Approach to the Hexahydroazepine Segment Based on RCM.
J. Org. Chem. 2000, 65, 1738-1742.

L. Ackermann, D. El Tom, A. Fürstner
Ruthenium Carbene Complexes with Imidazol-2-ylidene Ligands: Syntheses of Conduritol Derivatives Reveals Superior RCM Activity.
Tetrahedron 2000, 56, 2195-2202.

A. Fürstner
Multicomponent Catalysis for Reductive Bond Formations.
In: Organic Synthesis Highlights IV (H.-G. Schmalz, Ed.), Wiley-VCH, Weinheim, 2000, pp. 123-129.

C. W. Lehmann, A. Fürstner, T. Müller
Macrocyclic Substructure of Tricolorin A - The First Crystal Structure of a Resin Glycoside.
Z. Kristallogr. 2000, 215, 114-117.

A. Fürstner
Templated or Not Templated, that is the Question: Analysis of Some Ring Closure Reactions.
In: Templated Organic Synthesis (F. Diederich, P. J. Stang, Eds.), Wiley-VCH, Weinheim, 2000, pp. 249-273.

 

1999

A. Fürstner, O. Guth, A. Rumbo, G. Seidel
Ring Closing Alkyne Metathesis. Comparative Investigation of Two Different Catalyst Systems and Application to the Stereoselective Synthesis of Olfactory Lactones, Azamacrolides and the Macrocyclic Perimeter of the Marine Alkaloid Nakadomarin A.
J. Am. Chem. Soc. 1999, 121, 11108-11113.

A. Fürstner, H. Krause
Flexible Synthesis of Metacycloprodigiosin and Functional Derivatives Thereof.
J. Org. Chem. 1999, 64, 8281-8286.

A. Fürstner, J. Grabowski, C. W. Lehmann
Total Synthesis and Structural Refinement of the Cyclic Tripyrrole Pigment Nonylprodigiosin.
J. Org. Chem. 1999, 64, 8275-8280.

A. Fürstner, C. Mathes, C. W. Lehmann
Mo[N(t-Bu)(Ar)]3 Complexes as Catalyst Precursors: In Situ Activation and Application to Metathesis Reactions of Alkynes and Diynes.
J. Am. Chem. Soc. 1999, 121, 9453-9454.

A. Fürstner, T. Müller
Efficient Total Syntheses of Resin Glycosides and Analogues by Ring-Closing Olefin Metathesis.
J. Am. Chem. Soc. 1999, 121, 7814-7821.

A. Fürstner
Venturing into Catalysis Based Natural Product Synthesis.
Synlett 1999, 1523-1533.

A. Fürstner, A. F. Hill, M. Liebl, J. D. E. T. Wilton-Ely
Coordinatively Unsaturated Ruthenium Allenylidene Complexes: Highly Effective, Well Defined Catalysts for the Ring-Closure Metathesis of α,ω-Dienes and Dienynes.
Chem. Commun. (Cambridge, U. K.) 1999, 601-602.

L. Ackermann, A. Fürstner, T. Weskamp, F. J. Kohl, W. A. Herrmann
Ruthenium Carbene Complexes with Imidazolin-2-ylidene Ligands Allow the Formation of Tetrasubstituted Cycloalkenes by RCM.
Tetrahedron Lett. 1999, 40, 4787-4790.

A. Fürstner, G. Seidel, N. Kindler
Macrocycles by Ring-Closing-Metathesis, XI: Syntheses of (R)-(+)-Lasiodiplodin, Zeranol and Truncated Salicylihalamides.
Tetrahedron 1999, 55, 8215-8230.

A. Fürstner
Carbon-Carbon Bond Formations Involving Organochromium(III) Reagents.
Chem. Rev. (Washington, D. C.) 1999, 99, 991-1045.

A. Fürstner, T. Gastner, H. Weintritt
A Second Generation Synthesis of Roseophilin and Chromophore Analogues.
J. Org. Chem. 1999, 64, 2361-2366.

A. Fürstner, T. Gastner, J. Rust
Palladium Catalyzed Synthesis of the Furanoterpene Ircinin-4.
Synlett 1999, 29-32.

A. Fürstner, L. Ackermann
A Most User-Friendly Protocol for Ring Closing Metathesis Reactions.
Chem. Commun. (Cambridge, U. K.) 1999, 95-96.

A. Fürstner
The Reformatsky Reaction.
In: Organozinc Reagents: A Practical Approach (P. Knochel, P. Jones, Eds.), Oxford University Press, Oxford, 1999, pp. 287-305.

A. Fürstner, A. Hupperts, G. Seidel
Ethyl 5-Chloro-3-phenylindole-2-carboxylate (1H-Indole-2-carboxylic acid, 5-chloro-3-phenyl-, ethyl ester).
Org. Synth. 1999, 76, 142-150.

1998

F. Barbosa, V. Péron, G. Gescheidt, A. Fürstner
Radical Ions of Crownophanes Derived from Tetraphenylethene. Solution Structures and Ion Pairing Phenomena.
J. Org. Chem. 1998, 63, 8806-8814.

A. Fürstner
Ruthenium-Catalyzed Metathesis Reactions in Organic Synthesis.
Top. Organomet. Chem. 1998, 1, 37-72.

A. Fürstner
The McMurry Reaction and Related Transformations.
In: Transition Metals for Organic Synthesis and Fine Chemicals (M. Beller, C. Bolm, Eds.),
Wiley-VCH, Weinheim, 1998, pp. 381-401.

A. Fürstner, G. Seidel, H.-E. Mons, R. Mynott
NMR Investigations on the Solution Structure and Dynamic Behaviour of
1,2-Diphenyl-1,2-bis(trimethylsilyl)ethandiyldilithium.
Eur. J. Inorg. Chem. 1998, 1771-1774.

A. Fürstner, H. Szillat, B. Gabor, R. Mynott
Platinum- and Acid-Catalyzed Enyne Metathesis Reactions: Mechanistic Studies and Applications to the Syntheses of Streptorubin B and Metacycloprodigiosin.
J. Am. Chem. Soc. 1998, 120, 8305-8314.

A. Fürstner
Low-Valent Transition Metal Induced C-C-Bond Formations: Stoichiometric Reactions Evolving
into Catalytic Processes.
Pure Appl. Chem. 1998, 70, 1071-1076.

A. Fürstner, I. Konetzki
A Practical Synthesis of β-D-Mannopyranosides.
Tetrahedron Lett. 1998, 39, 5721-5724.

A. Fürstner, B. Tesche
Chemical Impact on a Seemingly "Inert" Material: An Electron Microscopic Case Study of
Titanium Activated by Chlorosilanes.
Chem. Mater. 1998, 10, 1968-1973.

A. Fürstner, M. Picquet, C. Bruneau, P. H. Dixneuf
Cationic Ruthenium Allenylidene Complexes as a New Class of Performing Catalysts for
Ring Closing Metathesis.
Chem. Commun. (Cambridge, U. K.) 1998, 1315-1316.

A. Fürstner, G. Seidel
Ring-Closing Metathesis of Functionalized Acetylene Derivatives: A New Entry into Cycloalkynes.
Angew. Chem., Int. Ed. 1998, 37, 1734-1736.

A. Fürstner, I. Konetzki
Total Synthesis of Caloporoside.
J. Org. Chem. 1998, 63, 3072-3080.

A. Fürstner
Multicomponent Catalysis for Reductive Bond Formations.
Chem.–Eur. J. 1998, 4, 567-570.

A. Fürstner, H. Weintritt
Total Synthesis of Roseophilin.
J. Am. Chem. Soc. 1998, 120, 2817-2825.

A. Fürstner, G. Seidel
Suzuki Reactions with B-Allyl-9-borabicyclo[3.3.1]nonane (B-Allyl-9-BBN).
Synlett 1998, 161-162.

A. Fürstner, T. Müller
Metathesis Route to Resin Glycosides: Formal Total Synthesis of Tricolorin A.
J. Org. Chem. 1998, 63, 424-425.

1997

A. Fürstner
Recent Advancements in Ring Closing Olefin Metathesis.
Top. Catal. 1997, 4, 285-299.

A. Fürstner, D. Koch, K. Langemann, W. Leitner, C. Six
Olefin Metathesis in Compressed Carbon Dioxide.
Angew. Chem., Int. Ed. Engl. 1997, 36, 2466-2469.

A. Fürstner, K. Langemann
Total Synthesis of (+)-Ricinelaidic Acid Lactone and of (−)-Gloeosporone Based on Transition Metal-Catalyzed C-C-Bond Formations.
J. Am. Chem. Soc. 1997, 119, 9130-9136.

A. Fürstner, T. Müller
The First Synthesis of a 10-Membered Ring by Olefin Metathesis: Jasmine Ketolactone.
Synlett 1997, 1010-1012.

A. Fürstner, K. Langemann
Macrocycles by Ring-Closing Metathesis.
Synthesis 1997, 792-803.

A. Fürstner, G. Seidel
Shortcut Syntheses of Naturally Occuring 5-Alkylresorcinols with DNA-Cleaving Properties.
J. Org. Chem. 1997, 62, 2332-2336.

A. Fürstner, H. Weintritt
Total Synthesis of the Potent Antitumor Agent Roseophilin: A Concise Approach to the Macrotricyclic Core.
J. Am. Chem. Soc. 1997, 119, 2944-2945.

1996

A. Fürstner
Syntheses of Biologically Relevant Target Molecules by Transition Metal-Induced
C-C-Bond Formation.
In: Organic Synthesis via Organometallics (OSM 5) (G. Helmchen, J. Dibo, D. Flubacher, B. Wiese, Eds.), Vieweg, Braunschweig, 1996, pp. 309-330.

A. Fürstner, K. Langemann
A Concise Total Synthesis of Dactylol via Ring Closing Metathesis.
J. Org. Chem. 1996, 61, 8746-8749.

A. Fürstner, N. Shi
Nozaki-Hiyama-Kishi Reactions Catalytic in Chromium.
J. Am. Chem. Soc. 1996, 118, 12349-12357.

A. Fürstner, K. Nikolakis
Ethynylation of Aryl Halides by a Modified Suzuki Reaction: Application to the Syntheses
of Combretastatin A-4, A-5 and Lunularic Acid.
Liebigs Ann. 1996, 2107-2113.

A. Fürstner, I. Konetzki
Synthesis of 2-Hydroxy-6-{[(16R)-β-D-mannopyranosyloxy)heptadecyl}benzoic Acid,
a Fungal Metabolite with GABAA Ion Channel Receptor Inhibiting Properties.
Tetrahedron 1996, 52, 15071-15078.

A. Fürstner, B. Bogdanović
New Developments in the Chemistry of Low-Valent Titanium.
Angew. Chem., Int. Ed. Engl. 1996, 35, 2442-2469.

A. Fürstner, H. Brunner
Preparation of Allyl-, Alkenyl- and of Functionalized Arylmanganese Reagents by Oxidative Insertion of Manganese-Graphite into Organic Halides.
Tetrahedron Lett. 1996, 37, 7009-7012.

A. Fürstner, N. Kindler
Macrocycle Formation by Ring-closing-Metathesis. 2. An Efficient Synthesis of Enantiomerically Pure (R)-(+)-Lasiodiplodin.
Tetrahedron Lett. 1996, 37, 7005-7008.

A. Fürstner, K. Langemann
Conformationally Unbiased Macrocyclization Reactions by Ring Closing Metathesis.
J. Org. Chem. 1996, 61, 3942-3943.

A. Fürstner, A. Ernst, H. Krause, A. Ptock
Low-Valent Titanium Induced Indole Formation: Syntheses of Secofascaplysin, Indolopyridocoline and an Endothelin-Receptor-Antagonist.
Tetrahedron 1996, 52, 7329-7344.

A. Fürstner, G. Seidel, C. Kopiske, C. Krüger, R. Mynott
Syntheses, Structures, and Complexation Properties of Photoresponsive Crownophanes.
Liebigs Ann. 1996, 655-662.

A. Fürstner, N. Shi
A Multicomponent Redox System Accounts for the First Nozaki-Hiyama-Kishi Reactions Catalytic in Chromium.
J. Am. Chem. Soc. 1996, 118, 2533-2534.

A. Fürstner
Supported Metals.
In: Active Metals. Preparation, Characterization, Applications (A. Fürstner, Ed.), VCH, Weinheim, 1996, pp. 381-426.

1995

A. Fürstner
Potassium-Graphite Laminate.
In: Encyclopedia of Reagents for Organic Synthesis, Vol. 6 (L. A. Paquette, Ed.), Wiley, Chichester, 1995, pp. 4226-4230.

A. Fürstner
Potassium on Alumina.
In: Encyclopedia of Reagents for Organic Synthesis, Vol. 6 (L. A. Paquette, Ed.), Wiley, Chichester, 1995, pp. 4180-4181.

A. Fürstner
Ethyl Bromozincacetate (Reformatsky Reagent).
In: Encyclopedia of Reagents for Organic Synthesis, Vol. 4 (L. A. Paquette, Ed.), Wiley, Chichester, 1995, pp. 2402-2408.

A. Fürstner, H. Weintritt, A. Hupperts
A New, Titanium-Mediated Approach to Pyrroles: First Syntheses of Lukianol A and of Lamellarin O Dimethyl Ether.
J. Org. Chem. 1995, 60, 6637-6641.

A. Fürstner, G. Seidel
Palladium-Catalyzed Arylation of Polar Organometallics Mediated by 9-Methoxy-9-borabicyclo[3.3.1]nonane: Suzuki Reactions of Extended Scope.
Tetrahedron 1995, 51, 11165-11176.

A. Fürstner, G. Seidel, B. Gabor, C. Kopiske, C. Krüger, R. Mynott
Unprecedented McMurry Reactions with Acylsilanes: Enedisilane Formation versus Brook Rearrangement.
Tetrahedron 1995, 51, 8875-8888.

A. Fürstner, A. Hupperts
Carbonyl Coupling Reactions Catalytic in Titanium and the Use of Commercial Titanium Powder for Organic Synthesis.
J. Am. Chem. Soc. 1995, 117, 4468-4475.

A. Fürstner, A. Ptock, H. Weintritt, R. Goddard, C. Krüger
Titanium-Induced Zipper Reactions.
Angew. Chem., Int. Ed. Engl. 1995, 34, 678-681.

A. Fürstner, D. N. Jumbam, N. Shi
Synthesis of Coumarins and Quinolones by Intramolecular Aldol Condensation Reactions of Titanium Enediolates.
Z. Naturforsch., B: Chem. Sci. 1995, 50, 326-332.

A. Fürstner, A. Ernst
Syntheses of Camalexin, Indolopyridocoline and Flavopereirine.
Tetrahedron 1995, 51, 773-786.

A. Fürstner, G. Seidel
'High-Surface Sodium' as a Reducing Agent for TiCl3.
Synthesis 1995, 63-68.

1994-1992

A. Fürstner, A. Hupperts, A. Ptock, E. Janssen
"Site Selective" Formation of Low-Valent Titanium Reagents: An "Instant" Procedure for the Reductive Coupling of Oxo Amides to Indoles.
J. Org. Chem. 1994, 59, 5215-5229.

A. Fürstner, D. N. Jumbam, G. Seidel
Syntheses of Zindoxifene and Analogues by Titanium-Induced Oxo-Amide Coupling.
Chem. Ber. 1994, 127, 1125-1130.

A. Fürstner, J.-P. Praly
Conversion of Glycosyl Azides via N-Bromoglycosylimines to Aldononitriles.
Angew. Chem., Int. Ed. Engl. 1994, 33, 751-753.

A. Fürstner, R. Singer, P. Knochel
A Convenient Preparation of Functionalized Arylzinc Compounds by the Reaction of Zinc/Silver Graphite with Aryl Iodides.
Tetrahedron Lett. 1994, 35, 1047-1050.

A. Fürstner
Synthesis and Reductive Elimination Reactions of Aryl Thioglycosides.
Liebigs Ann. Chem. 1993, 1211-1217.

W. Oppolzer, A. Fürstner
Rhodium(I)-Catalyzed 'Metallo-ene' Cyclizations/β-Eliminations.
Helv. Chim. Acta 1993, 76, 2329-2337.

A. Fürstner, J. Baumgartner
A Carbohydrate Approach to Polyol Fragments of Amphotericin and the Trienomycin and Mycotrienin Antibiotics.
Tetrahedron 1993, 49, 8541-8560.

A. Fürstner
Chemistry of and with Highly Reactive Metals.
Angew. Chem., Int. Ed. Engl. 1993, 32, 164-189.

A. Fürstner, D. N. Jumbam
Reversed Chemoselectivity in Titanium-Induced Coupling Reactions: Syntheses of Salvadoricine and Diazepam.
J. Chem. Soc., Chem. Commun. 1993, 211-212.

A. Fürstner, J. Baumgartner, D. N. Jumbam
Unprecedented Influence of Azides and the Effect of Bulky Groups on Zinc-Induced Reductions of Deoxy Halogeno Sugars.
J. Chem. Soc., Perkin Trans. 1 1993, 131-138.

A. Fürstner, D. N. Jumbam
Titanium-Induced Syntheses of Furans, Benzofurans and Indoles.
Tetrahedron 1992, 48, 5991-6010.

A. Fürstner, H. Weidmann
Aliphatic Carbonyl Compounds: Aliphatic Aldehydes.
In: Second Supplements to the 2nd Edition of Rodd’s Chemistry of Carbon Compounds, Vol. I C (M. Sainsbury, Ed.), Elsevier, Amsterdam, 1992, pp. 1-35.
 

1991-1986

A. Fürstner, D. N. Jumbam, H. Weidmann
Titanium-Induced Syntheses of Furans and Indoles.
Tetrahedron Lett. 1991, 32, 6695-6696.

A. Fürstner, G. Kollegger, H. Weidmann
Selective Formation of Alkenes from Trimethylsilylmethyl Ketones and from Acylsilanes.
J. Organomet. Chem. 1991, 414, 295-305.

A. Fürstner, F. Hofer, H. Weidmann
Comparative Investigation of the Morphology of Nickel- and Copper-Graphite.
Carbon 1991, 29, 915-919.

A. Fürstner, D. Jumbam, J. Teslic, H. Weidmann
Metal-Graphite Reagents in Carbohydrate Chemistry. 8. The Scope and Limitations of the Use of Zinc/Silver-Graphite in the Synthesis of Carbohydrate-Derived Substituted Hex-5-enals and Pent-4-enals.
J. Org. Chem. 1991, 56, 2213-2217 [Erratum: 5965].

A. Fürstner
Metal-Graphite Reagents in Carbohydrate Chemistry, IX. Fragmentations of 1-Deoxy-1-iodo-2,3;4,5-di-O-isopropylidene Pentitols.
Tetrahedron Lett. 1990, 31, 3735-3738.

A. Fürstner, U. Koglbauer, H. Weidmann
Metal-Graphite Reagents in Carbohydrate Chemistry, VII. Fragmentation of O-Alkylidene-deoxy Halo Sugars.
J. Carbohydr. Chem. 1990, 9, 561-570.

A. Fürstner, H. Weidmann
Synthesis of All 2,3,4-Trimethoxy-5-hexenal (5,6-Dideoxy-2,3,4-tri-O-methylaldohex-5-enose) Isomers.
J. Org. Chem. 1990, 55, 1363-1366.

A. Fürstner, F. Hofer, H. Weidmann
Preparation, Structure, and Use of Platinum-Graphite in Hydrogenation Reactions.
J. Catal. 1989, 118, 502-506.

A. Fürstner
Recent Advancements in the Reformatsky Reaction.
Synthesis 1989, 571-590.

A. Fürstner, H. Weidmann
Highly Selective Metal-Graphite-Induced Reductions of Deoxy Halo Sugars.
J. Org. Chem. 1989, 54, 2307-2311.

A. Fürstner, H. Weidmann
A Simple and Efficient New Glycal Synthesis.
J. Carbohydr. Chem. 1988, 7, 773-783.

A. Fürstner, H. Weidmann
Efficient Formation and Cleavage of Disilanes by Potassium-Graphite. Silylation with
Silyl Metal Reagents.
J. Organomet. Chem. 1988, 354, 15-21.

A. Fürstner, H. Weidmann, F. Hofer
Analytical Electron Microscopy Discloses Actual Structure of Zinc-Graphite.
J. Chem. Soc., Dalton Trans. 1988, 2023-2026.

A. Fürstner, R. Csuk, C. Rohrer, H. Weidmann
Magnesium- and Titanium-Induced Reductive Coupling of Carbonyl Compounds:
Efficient Syntheses of Pinacols and Alkenes.
J. Chem. Soc., Perkin Trans. I 1988, 1729-1734.

R. Csuk, B. I. Glänzer, A. Fürstner
Graphite-Metal Compounds.
Adv. Organomet. Chem. 1988, 28, 85-137.

A. Fürstner
α-Bromo-, α-Chloro-, and α-Trimethylsilyl-Zinc Ester Enolates. New and Universal Reformatsky Type Darzens and Peterson Reactions.
J. Organomet. Chem. 1987, 336, C33-C36.

A. Fürstner, H. Weidmann
Hochreaktives Titan auf Graphit. Ein universelles Reduktionsmittel zur Alkenkupplung von Carbonylverbindungen.
Synthesis 1987, 1071-1075.

R. Csuk, A. Fürstner, H. Weidmann
A Simple and Efficient New Synthesis of Vicinal Diols by Reductive Coupling of Carbonyl Compounds.
J. Chem. Soc., Chem. Commun. 1986, 1802-1803.

R. Csuk, B. I. Glänzer, A. Fürstner, H. Weidmann, V. Formacek
Formation of a Hexoseptanose by Unusual Rearrangements of a Furanoid Glycal.
Carbohydr. Res. 1986, 157, 235-241.

R. Csuk, A. Fürstner, H. Sterk, H. Weidmann
Synthesis of Carbohydrate Derived α-Methylene-γ-Lactones by Diastereoselective, Low Temperature Reformatsky-Type Reactions.
J. Carbohydr. Chem. 1986, 5, 459-467.

R. Csuk, A. Fürstner, H. Kalchhauser, C. Kratky, U. Wagner, H. Weidmann
Zur Stereoanalyse von Diastereomeren 5-C-Ethoxycarbonylmethylen-hexofuranurono-6,3-lactonen und -3,6-anhydrofuranosen.
J. Carbohydr. Chem. 1986, 5, 401-409.

R. Csuk, A. Fürstner, B. I. Glänzer, H. Weidmann
A New, Zinc-Promoted Synthesis of 1,4-(1,5)-Anhydro-2-deoxy-pent-(hex)-1-enitols (Furanoid and Pyranoid Glycals).
J. Chem. Soc., Chem. Commun. 1986, 1149-1150.

R. Csuk, A. Fürstner, H. Weidmann
Synthesis and Rearrangement Reactions of C-Alkylidene Carbohydrates.
J. Carbohydr. Chem. 1986, 5, 271-285.

R. Csuk, A. Fürstner, H. Weidmann
Efficient, Low Temperature Reformatsky Reactions of Extended Scope.
J. Chem. Soc., Chem. Commun. 1986, 775.

R. Csük, A. Fürstner, H. Weidmann
Branching of Ketosugars by Ethyl Trimethylsilylacetate/Tetra-n-butylammonium Fluoride.
J. Carbohydr. Chem. 1986, 5, 77-82.

 

since 2013     Member of the Editorial Board "Comptes Rendus Chimie"
since 2012     Member of the International Advisory Board of "ChemPlusChem"
since 2010     Member of the Editorial Board „Angewandte Chemie" and of the Advisory Board
                    "Israel Journal of Chemistry"
since 2009     Member of the Advisory Board "ChemCatChem"
2009-2013     Member of the Advisory Board "Synthesis" and "Synlett"
since 2007     Member of the Advisory Board "Nachrichten aus der Chemie"
since 2006     Member of the Advisory Boards "ChemMedChem"
since 2005     Member of the Editorial Advisory Board "Progress in Heterocylic Chemistry"
2002-2004     Member of the Editorial Advisory Board "Journal of Organic Chemistry“
since 2000     Member of the Advisory Board "Advanced Synthesis & Catalysis"
since 1997     Member of the Editorial Board "Topics in Organometallic Chemistry"

Research Topics

Alkyne Metathesis
Alkyne Metathesis

Alkyne Metathesis

Whereas alkene metathesis is a striking success in the catalytic arena and was rapidly embraced by the synthetic community, the related metathesis of alkynes is much less commonly used. However, the reaction has several assets: it benefits from a surprisingly strong driving force and is mechanistically well understood; alkyne metathesis is unambiguous in its stereochemical consequences when combined with controlled semi-reduction; alkynes are amenable to a large variety of post-metathesis transformations, most notably by activation with carbophilic Lewis acid catalysts.

Our group is committed to demonstrate the remarkable performance of this transformation in synthesis. To this end, we are engaged in the development of new alkyne metathesis catalysts and in understanding their mode of action. The latest generation of catalysts described by our group is molybdenum-nitrides and molybdenum-alkylidynes endowed with silanolate ligands. These complexes combine a previously unknown level of reactivity with an exquisite functional group tolerance. At the same time, they can easily be rendered air stable, which makes them highly practical and user-friendly.

In parallel work, our group is constantly probing and expanding the preparative scope of alkyne metathesis by applications to structurally complex and biologically relevant target molecules. The projects encompass prostaglandins, peptides, alkaloids, macrolide antibiotics and various anti-cancer agents. Prominent examples in the past were epothilone, the latrunculins, cruentaren A, amphidinolide V, the ecklonialactones, and lactimidomycin.
 

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Alkene Metathesis
Alkene Metathesis

Alkene Metathesis

The keen interest in alkene metathesis dates back to the outset of Prof. Fürstner's independent career in the early 1990s. Our initial work showed the outstanding performance of the then brand new molybdenum and ruthenium alkylidene complexes developed by Schrock and Grubbs, respectively, for the preparation of medium-sized and macrocyclic rings. Rules were spelled out how to implement ring closing metathesis into retrosynthetic planning and examples were given, which demonstrated the complementary logic of this transformation.

Subsequent work aimed at the development of readily accessible and even more efficient catalysts (ruthenium allenylidenes and -indenylidenes, “second generation” ruthenium carbenes endowed with NHC ligands etc.), some of which are now commercially available. A rapid parallel assay was established to test the performance of new catalysts by IR thermography. Moreover, the first examples of metathesis reactions in supercritical carbon dioxide were reported, which showed the advantages of this particular medium in the formation of macrocyclic fragrance ingredients as well as in ROMP polymerizations.

Significant efforts are made to demonstrate the strategic advantages of alkene metathesis for advanced organic synthesis. Starting from early work on macrocyclic musk, the group has gone on to the total synthesis of highly complex polyketides, alkaloids, terpenes, and glycolipids.

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π-Acid Catalysis
π-Acid Catalysis

π-Acid Catalysis

Catalysis based on the activation of p-systems with the aid of carbophilic Lewis acids such as Pt(2+) and Au(1+) has gained considerable momentum. Except for a few pioneering studies, this field was virtually inexistent until the late 1990’s but is currently one of the most rapidly growing areas of homogeneous catalysis.

As early as 1998, the Fürstner group proposed a unifying mechanism, which guided our investigations during the following years. This hypothesis-driven approach led to the discovery of several new reactions, which were successfully scrutinized by several natural product total syntheses. Moreover, we are dedicated to the characterization of pertinent reactive intermediates to refine the mechanistic understanding for gold and platinum catalysis. Likewise, the development of practical asymmetric variants is actively pursued.

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Iron Catalysis
Iron Catalysis

Iron Catalysis

We are interested in the development of catalysts based on cheap, non-toxic, benign and readily available transition metals as substitutes for traditional noble metal complexes. Although not limited to, iron catalysis is prominently featured in this context.

Particular attention is paid to the development of iron catalysts for cross coupling, cycloisomerization reactions, cycloadditions of unactivated substrates, and carbometalations of π-bonds. Considerable efforts are made to identify, isolate and characterize short-lived and, in part, highly reactive organoiron intermediates to gain a better understanding for the largely unknown mechanisms of such iron-catalyzed C-C bond-forming reactions. Applications of the new methods to the preparation of relevant target molecules complement our portfolio.

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Novel Concepts for Catalysis
Novel Concepts for Catalysis

Novel Concepts for Catalysis

Various lines of research are pursued by which we intend to establish new principles for catalysis and to develop conceptually novel ligand architectures.

Redox Catalysis:
We are striving to replace notoriously stoichiometric reactions of proven versatility by catalytic processes. Successful examples are the first Nozaki-Hiyama-Kishi (NHK) reactions catalytic in chromium as well as carbonyl coupling reactions catalytic in titanium. The latter opened a new entry into indoles and various other types of aromatic heterocycles.

Cross Coupling:
Our group has introduced the “9-methoxy-9-BBN variant” of the Suzuki reaction as a highly versatile and base-free procedure for cross coupling. Moreover, an improved method for Stille-Migita reactions was recently described, which is applicable to polyfunctionalized and sensitive substrates.

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Carbene Ligands:
Whereas the σ-donor qualities of N-heterocyclic carbenes (NHC's) are undisputed and extensively used in homogeneous catalysis, the π-acceptor properties of such ligands are often considered negligible. However, recent studies from this laboratory showed that the acceptor properties of NHCs can be up-regulated to the extent that they start dictating the observed reactivity. Therefore the general perception of this important class of ligands may need to be revised. Moreover, we proposed several alternative design principles for stable singlet carbenes, including amino-ylide carbenes (AYC’s), carbenes stabilized by lateral enamines, and push-pull carbene structures.

Coordination Chemistry at Carbon:
Organic molecules are commonly understood as substances based on carbon atoms which involve all four valence electrons in bonding. If two electrons form a lone-pair, one crosses the traditional borders to coordination chemistry and/or enters the realm of reactive intermediates. Compounds, wherein a carbon atom configures all four valence electrons in form of two lone-pairs may seem elusive at first sight. Following insightful early reports and recent computational studies, however, our group is investigating the preparation and reactivity of compounds, in which carbon serves as the central atom of a complex. The description of certain carbogenic materials as coordination compounds differs fundamentally from the common understanding of organic chemistry.

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Total Synthesis and Evaluation of Natural Products
Total Synthesis and Evaluation of Natural Products

Total Synthesis and Evaluation of Natural Products

A significant part of our work is dedicated to the application of organometallic catalysis to the total synthesis of structurally complex natural products of biological significance; where indicated, we are also committed to prepare analogues by “diverted total synthesis” for further evaluation.

From the chemical viewpoint, all projects intend to scrutinize the synthetic methods of interest to our group. We wish to develop syntheses that are concise, convergent, productive and scalable; ideally, they should be largely catalysis-based and require a minimum of protecting group manipulations. With regard to the targets, our choice is based on considerations of structural complexity, biological activity, and non-availability of meaningful amounts from the natural sources. Biological assessments of the compounds prepared in the laboratory are carried out in close collaboration with external partners.

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  •  Andreas Ahlers

    Ahlers, Andreas

    +49(0)208/306-2384

    ahlers((atsign))kofo.mpg.de

  •  Alexander Arlt

    Arlt, Alexander

    Dec 09 – Apr 13 PhD Student

  •  Tamara Arto Suárez

    Arto Suárez, Tamara

    Sep 2013 – Dec 2013 Visiting PhD Student

  •  Stefan Benson

    Benson, Stefan

    Feb 08 – May 11 PhD Student

  •  Lennart Brewitz

    Brewitz, Lennart

    +49(0)208/306-2382

    brewitz((atsign))kofo.mpg.de

  • Dr. Alicia Casitas Montero

    Dr. Casitas Montero, Alicia

    +49(0)208/306-2381

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  • Dr. Wojciech Chaładaj

    Dr. Chaładaj, Wojciech

    Mar 11 – Mar 12 Post-doc

  • Dr. Matthieu Corbet

    Dr. Corbet, Matthieu

    Dec 09 – Apr 11 Post-doc

  • Dr. Teresa de Haro García

    Dr. de Haro García, Teresa

    Jun 12 – Nov 13 Post-doc

  • Dr. Michael Fuchs

    Dr. Fuchs, Michael

    +49(0)/306-2385

    fuchs((atsign))kofo.mpg.de

  • Prof. Dr. Alois Fürstner

    Prof. Dr. Fürstner, Alois

    +49(0)208/306-2342

    fuerstner((atsign))kofo.mpg.de

  • Dr. Tsutomu Fukuda

    Dr. Fukuda, Tsutomu

    Jul 12 – Jul 13 Visiting Scientific Co-worker

  •  Daniel Gallenkamp

    Gallenkamp, Daniel

    Jan 09 – Dec 11 PhD Student

  •  Morgane Gaydou

    Gaydou, Morgane

    Jul 12 – Sep 12 Visiting PhD Student

  •  Konrad Gebauer

    Gebauer, Konrad

    +49(0)208/306-2381

    gebauer((atsign))kofo.mpg.de

  • Dr. Shinya Handa

    Dr. Handa, Shinya

    Apr 10 – Oct 11 Post-doc

  •  Chris Hartding

    Hartding, Chris

    +49(0)208/306-2384

    hartding((atsign))kofo.mpg.de

  •  Sarah Henze

    Henze, Sarah

    +49(0)208/306-2385

    henze((atsign))kofo.mpg.de

  •  Johannes Heppekausen

    Heppekausen, Johannes

    Aug 09 – Nov 12 PhD Student

  •  Laura Hoffmeister

    Hoffmeister, Laura

    +49(0)208/306-2381

    hoffmeister((atsign))kofo.mpg.de

  •  Marina Ilg

    Ilg, Marina

    +49(0)208/306-2382

    ilg((atsign))kofo.mpg.de

  • Dr. Kévin Jouvin

    Dr. Jouvin, Kévin

    Sep 12 – Feb 14 Post-doc

  • Dr. Nina Kausch-Busies

    Dr. Kausch-Busies, Nina

    Jan 11 – Jan 12 Scientific Co-worker

  • Dr. Azusa Kondoh

    Dr. Kondoh, Azusa

    Apr 10 – Mar 12 Post-doc

  •  Helga Krause

    Krause, Helga

    +49(0)208/306-2382

    krause((atsign))kofo.mpg.de

  • Dr. Aaron Lackner

    Dr. Lackner, Aaron

    +49(0)208/306-2382

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  •  Daniel Laurich

    Laurich, Daniel

    +49(0)208/306-2384

    dlaurich((atsign))kofo.mpg.de

  •  Konrad Lehr

    Lehr, Konrad

    Oct 10 – Dec 13 PhD Student

    lehr((atsign))kofo.mpg.de

  •  Roswitha Leichtweiß

    Leichtweiß, Roswitha

    +49(0)208/306-2389

    leichtweiss((atsign))kofo.mpg.de

  •  Jennifer Lenartowicz

    Lenartowicz, Jennifer

    +49(0)208/306-2383

    lenartow((atsign))kofo.mpg.de

  • Dr. Rudy Lhermet

    Dr. Lhermet, Rudy

    +49(0)208/306-2381

    lhermet((atsign))kofo.mpg.de

  •  Monika Lickfeld

    Lickfeld, Monika

    +49(0)208/306-2341/-2151

    lickfeld((atsign))kofo.mpg.de

  • Dr. Josep Llaveria Cros

    Dr. Llaveria Cros, Josep

    Oct 11 – Feb 14 Post-doc

  • Dr. Damien Mailhol

    Dr. Mailhol, Damien

    +49(0)208/306-2381

    mailhol((atsign))kofo.mpg.de

  • Dr. Luca Mantilli

    Dr. Mantilli, Luca

    Nov 11 – Apr 13 Post-doc

  •  Ana Martín Lasanta

    Martín Lasanta, Ana

    Sep 11 – Dec 11; Dec 12 – Feb 13 Visiting PhD Student

  • Dr. Xiaowei Miao

    Dr. Miao, Xiaowei

    Dec 10 – Nov 11 Post-doc

  • Dr. Kevin Micoine

    Dr. Micoine, Kevin

    Nov 09 – Sep 11 Post-doc

  •  Yasuo Nakagawa

    Nakagawa, Yasuo

    Aug 12 – Oct 12 Visiting PhD Student

  •  Peter Persich

    Persich, Peter

    Oct 10 – Dec 13 PhD Student

    persich((atsign))kofo.mpg.de

  •  Gerit Pototschnig

    Pototschnig, Gerit

    Jun 13 – Nov 13 Visiting PhD Student

  •  Johannes Preindl

    Preindl, Johannes

    +49(0)208/306-2383

    preindl((atsign))kofo.mpg.de

  •  Karin Radkowski

    Radkowski, Karin

    +49(0)208/306-2385

    radkowski((atsign))kofo.mpg.de

  • Dr. Christopher S. Regens

    Dr. Regens, Christopher S.

    May 09 – Jul 11 Post-doc

  •  Anna Rudo

    Rudo, Anna

    Nov 12 – Feb 13 PhD Student

  •  Stephan Rummelt

    Rummelt, Stephan

    +49(0)208/306-2383

    rummelt((atsign))kofo.mpg.de

  •  Sebastian Schaubach

    Schaubach, Sebastian

    +49(0)208/306-2384

    schaubach((atsign))kofo.mpg.de

  •  Torsten Scholl

    Scholl, Torsten

    Jan 09 – Aug 11 Permanent Staff

  •  Saskia Schulthoff

    Schulthoff, Saskia

    +49(0)208/306-2383

    schulthoff((atsign))kofo.mpg.de

  •  Günter Seidel

    Seidel, Günter

    Apr 65 – Feb 69; Oct 72 – Feb 14 Permanent Staff

  •  Heiko Sommer

    Sommer, Heiko

    +49(0)208/306-2384

    hsommer((atsign))kofo.mpg.de

  •  Robert Stade

    Stade, Robert

    Sep 08 – Aug 11 PhD Student

  • Dr. Chang-Liang Sun

    Dr. Sun, Chang-Liang

    +49(0)208/306-2381

    sun((atsign))kofo.mpg.de

  • Dr. Basker Sundararaju

    Dr. Sundararaju, Basker

    Oct 11 – Sep 13

  •  Yudai Suzuki

    Suzuki, Yudai

    Jun 13 – Sep 13 Visiting PhD Student

  • Dr. Akira Takagi

    Dr. Takagi, Akira

    +49(0)206/306-2385

    takagi((atsign))kofo.mpg.de

  •  Henrik Teller

    Teller, Henrik

    Nov 08 – Dec 11 PhD Student

  •  Sandra Tobegen

    Tobegen, Sandra

    +49(0)208/306-2383

    tobegen((atsign))kofo.mpg.de

  •  Yoshihiro Ueda

    Ueda, Yoshihiro

    Oct 11 – Dec 11 Visiting PhD Student

  •  Felix Ungeheuer

    Ungeheuer, Felix

    +49(0)208/306-2383

    ungeheuer((atsign))kofo.mpg.de

  • Dr. Gaëlle Valot

    Dr. Valot, Gaëlle

    Oct 11 – Mar 14 Post-doc

  • Dr. Dieter Weber

    Dr. Weber, Dieter

    +49(0)208/306-2382

    dweber((atsign))kofo.mpg.de

  • Dr. Matthew Webster

    Dr. Webster, Matthew

    Jan 10 – May 11 Post-doc

  •  Jens Willwacher

    Willwacher, Jens

    +49(0)208/306-2385

    willwacher((atsign))kofo.mpg.de

  • Dr. Akira Yada

    Dr. Yada, Akira

    Apr 10 – Jun 11 Post-doc