Publikationen von Manfred T. Reetz

Zeitschriftenartikel (467)

2018
Zeitschriftenartikel
Li, G.; Wang, J.; Reetz, M. T. Biocatalysts for the pharmaceutical industry created by structure-guided directed evolution of stereoselective enzymes. Bioorganic & Medicinal Chemistry 2018, 26, 1241–1251.
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Li, A.; Acevedo-Rocha, C. G.; Sun, Z.; Cox, T.; Xu, J. L.; Reetz, M. T. Beating Bias in the Directed Evolution of Proteins: Combining High-Fidelity on-Chip Solid-Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction. Chembiochem 2018, 19, 221–228.
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Qu, G.; Lonsdale, R.; Yao, P.; Li, G.; Liu, B.; Reetz, M. T.; Sun, Z. Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis. Chembiochem 2018, 19, 239–246.
Zeitschriftenartikel
Reetz, M. T. Combinatorial Libraries Reloaded[1]. Israel Journal of Chemistry 2018, 58, 52–60.
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Sun, Z.; Wu, L.; Bocola, M.; Chan, H. C. S.; Lonsdale, R.; Kong, X.-D.; Yuan, S.; Zhou, J.; Reetz, M. T. Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. Journal of the American Chemical Society 2018, 140, 310–318.
2017
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Li, G.; Fürst, M. J. L. J.; Mansouri, H. R.; Ressmann, A. K.; Ilie, A.; Rudroff, F.; Mihovilovic, M. D.; Fraaije, M. W.; Reetz, M. T. Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution. Organic & Biomolecular Chemistry 2017, 15, 9824–9829.
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Li, G.; Maria-Solano, M. A.; Romero-Rivera, A.; Osuna, S.; Reetz, M. T. Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution. Chemical Communications 2017, 53, 9454–9457.
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Wang, J.; Ilie, A.; Yuan, S.; Reetz, M. T. Investigating Substrate Scope and Enantioselectivity of a Defluorinase by a Stereochemical Probe. Journal of the American Chemical Society 2017, 139, 11241–11247.
Zeitschriftenartikel
Wang, J.; Ilie, A.; Reetz, M. T. Chemo- and Stereoselective Cytochrome P450-BM3 Catalyzed Sulfoxidation of 1-Thiochroman-4-ones. Advanced Synthesis & Catalysis 2017, 359, 2056–2060.
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Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T. Correction: Simultaneous engineering of an enzyme’s entrance tunnel and active site: the case of monoamine oxidase MAO-N. Chemical Science 2017, 8, 4666–4666.
Zeitschriftenartikel
Acevedo, J. P.; Reetz, M. T.; Asenjo, J. A.; Parra, L. P. One-Step Combined Focused epPCR and Saturation Mutagenesis for Thermostability Evolution of a New Cold-Active Xylanase. Enzyme and Microbial Technology 2017, 100, 60–70.
Zeitschriftenartikel
Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T. Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N. Chemical Science 2017, 8, 4093–4099.
Zeitschriftenartikel
Wang, J.; Li, G.; Reetz, M. T. Enzymatic site-selectivity enabled by structure-guided directed evolution. Chemical Communications 2017, 53, 3916–3928 .
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Li, A.; Wang, B.; Ilie, A.; Dubey, K. D.; Bange, G.; Korendovych, I. V.; Shaik, S.; Reetz, M. T. A redox-mediated Kemp eliminase. Nature Communications 2017, 8, 14876.
Zeitschriftenartikel
Qiao, Y.; Theyssen, N.; Eifert , T.; Liauw, M. A.; Francio, G.; Schenk , K.; Leitner, W.; Reetz, M. T. Concerning the Role of Supercritical Carbon Dioxide in SN1 Reactions. Chemistry – A European Journal 2017, 23, 3898–3902.
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Ilie, A.; Roiban, G.-D.; Reetz, M. T. Di–tert–butyl N,N-diethylphosphoramidite as an Air Stable Ligand for Suzuki-Miyaura and Buchwald-Hartwig Reactions. ChemistrySelect 2017, 2, 1392–1397.
2016
Zeitschriftenartikel
Luo, X.-J.; Zhao, J.; Li, C.-X.; Bai, Y.-P.; Reetz, M. T.; Yu, H.-L.; Xu, J.-H. Combinatorial evolution of phosphotriesterase toward a robust malathion degrader by hierarchical iteration mutagenesis. Biotechnology and Bioengineering 2016, 113, 2350–2357.
Zeitschriftenartikel
Sun, Z.; Lonsdale, R.; Li, G.; Reetz, M. T. Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- versus Double-Code Saturation Mutagenesis. Chembiochem 2016, 17, 1865–1872.
Zeitschriftenartikel
Li, A.; Ilie, A.; Sun, Z.; Lonsdale, R.; Xu, J.-H.; Reetz, M. T. Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution. Angewandte Chemie International Edition 2016, 55, 12026–12029.
Zeitschriftenartikel
Sun, Z.; Torres Salas, P.; Siirola, E.; Lonsdale, R.; Reetz, M. T. Exploring productive sequence space in directed evolution using binary patterning versus conventional mutagenesis strategies. Bioresources and Bioprocessing 2016, 3, 1–8.
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