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Stereoselective Synthesis and Catalysis

We are a young and dynamic newly established Max-Planck Research Group aiming to address problems at the interface of classical organic chemistry, asymmetric catalysis and chemical biology. Our interests invariably stem from the desire to explore unconventional reactivity profiles of organic compounds.

Nuno Maulide

Dr. Nuno Maulide

Since 2009
Max-Planck Research Group Leader (W2/Associate Professor without tenure) at the Max-Planck Institut für Kohlenforschung
2007-2008
Postdoctoral studies at Stanford University, USA (Prof. Barry M. Trost), on ruthenium-catalysed bond-forming reactions.
2007
Ph.D. from Université catholique de Louvain, Louvain-la-Neuve, Belgium (Prof. István E. Markó) on new bifunctional reagents for the synthesis of cyclic compounds.
2004
Masters Degree from Ecole Polytechnique (Paris, France) and Université catholique de Louvain (Louvain-la-Neuve, Belgium).
2003
Chemistry Degree from the Instituto Superior Técnico, Lisbon (6-month internship at Clariant AG, Basel).
1979
Born in Lisbon, Portugal
2012
ADUC Jahrespreis für Habilitanden (2011/2012)
2011
European Research Council (ERC) Starting Grant
2010
Thieme Journal Award
2009
Member of the Global Young Faculty
2009
Appointed Group Leader by the Max-Planck Society
2007
Post-Doctoral Fellowship from the Fundação para a Ciência e Tecnologia (FCT)
2007
Laureate of the DSM Awards in Science & Technology 2007
2007
Roche Award
2006
Best oral communication at the Frühjahrssymposium 2006
2005
Best oral communication at the YoungChem 2005
2005
Aspirant FNRS at the Université catholique de Louvain
2005
Lhoist R&D Prize
2003
Ph.D. Scolarship from the Fonds pour la Recherche dans l'Industrie et l'Agriculture (FRIA)
2002
IAESTE scolarship for a 6-month industrial internship (Clariant AG, Basel)
2002
Merit scolarship for excellence in Chemistry studies
2001
Merit scolarship for excellence in Chemistry studies
2000
Merit scolarship for excellence in Chemistry studies

  • April, 2012
    Upcoming lectures:
    - Ecole Polytechnique Fédérale de Lausanne (EPFL), 28 November 2012, Lausanne (Switzerland) (upcoming)
    - International Conference “Catalysis in Organic Synthesis” (ICCOS-2012), 15-20 September 2012, Moscow (Russia) (Invited Speaker, upcoming)
    - 7th Asian-European Symposium, 22-25 July 2012, Tarragona (Spain) (Keynote, upcoming)
    - Rencontres de Chimie Organique VII, 14-16 June 2012, Marseille (France) (Keynote, upcoming)
    - Technische Universität Darmstadt, 23 April 2012, Darmstadt (Germany) (upcoming)
    - ‘Monheimer Kolloquium’, Bayer CropScience, 30 March 2012, Monheim (Germany)
     
  • March, 2012
    Maria Teresa Oliveira got the 1st Oral Presentation Award in the 14th JCF-Frühjahrssymposium in Rostock. Congratulations!

    Dr. Nuno Maulide gives a short interview to Portuguese radio. You can listen to it here (in Portugese):
    http://tv2.rtp.pt/multimediahtml/progAudio.php?prog=3988

As of now you will find all relevant news from our work group in this section.

The list of all previous presentations held by Dr. Maulide will remain as it is now, new presentations will be updated as News.

_________________________________________________________

 - Chemiedozententagung 2012, 5-6 March 2012, Freiburg, DE
- Université Pierre et Marie Curie, 13 February 2012, Paris, FR
- Sociedade Portuguesa de Química, 9 February 2012, Lissabon, PT
- Phillips-Universität Marburg, 6 February 2011, Marburg, DE.
- Rijksuniversiteit Groningen, 8 December 2011, Groningen, NL.
- Humboldt-Universität Berlin, 23 November 2011, Berlin, DE.
- Faculdade de Farmácia de Lisboa, 11 November 2011, Lissabon, PT.
- Swiss Chemical Society Fall Meeting, 9 September 2011, Lausanne, CH.
- GDCh Wissenschaftsforum, 4-7 September 2011, Bremen, DE.
- ESF-COST High-Level Conference “Natural Products Chemistry, Biology and
   Medicine IV”, 28 Aug.-2 Sep. 2011, Acquafredda di Maratea, IT.
- European Symposium on Organic Chemistry (ESOC), 10-15 July 2011, Crete, GR.
- 22nd Encontro Nacional de Quimica, 3-6 July 2011, Braga, PT.
- Bayer Healthcare, 21 June 2011, Wuppertal, DE.
- Ludwigs-Maximilian-Universität München, 16 May 2011, Munich, DE.
- Chemiedozententagung 2011, 14-15 March 2011, Mainz, DE.
- Universität zu Köln, 14 January 2011, Cologne, DE (invited lecture).
- Ruprechts-Karl-Universität Heidelberg, 22 July 2010, Heidelberg, DE (invited lecture).
- Ruhr-Universität Bochum, 16 July 2009, Bochum, DE (invited lecture).
- 8th ENQO, 1-3 July 2009, Aveiro, PT (invited lecture).
- Max-Planck Institut für Kohlenforschung, 2 December 2008, Mülheim, DE (invited lecture).
- Instituto Superior Técnico, 24 November 2008, Lisbon, PT (invited lecture).
- 1st PyCHEM, 15-17 October 2008, Lisbon, PT.
- Syngenta AG, 2 April 2008, Stein, CH (invited lecture).
- SNWG Symposium of the Max-Planck Society, 7-9 February 2008, Berlin, DE.
- Ph.D. Final Examination, 20 July 2007, Louvain-la-Neuve, BE.
- DSM Awards in Science & Technology 2007, 3-5 June 2007, La Hulpe, BE.
- Roche Symposium for Leading Scientists of the Next Decade, 14-16 March 2007, Basel, CH.
- Journées de Rencontre des Jeunes Chimistes de la SRC, 8-9 March 2007, Herbeumont, BE.
- 10th Sigma-Aldrich Organic Synthesis Meeting, 7 December 2006, Spa, BE.
- 10th Ph.D. Students’ Day, 19 May 2006, Louvain-la-Neuve, BE.
- Ecole Doctorale de Chimie, 29 March 2006, Louvain-la-Neuve, BE (invited lecture).
- Frühjahrssymposium 2006, 16-18 March 2006, Konstanz, DE.
- SAJEC 2005, 17-19 October 2005, Lille, FR.
- European Young Chemists’ Congress (YoungChem), 12-16 October 2005, Rydzyna, PL.
- Journées de Rencontre des Jeunes Chimistes de la SRC, 22-25 March 2005, Cul-des-S., BE.

 

2012

29) Davide Audisio, Marco Luparia, Maria Teresa Oliveira, Frédéric Frébault, Dina Klütt and Nuno Maulide*,
Angew. Chem. 2012, accepted (doi: 10.1002/anie.201202853)

28) Sebastian Klimczyk, Xueliang Huang, Christophe Farès and Nuno Maulide*,
Sulfoxide-mediated Umpolung of alkali halide salts
Org. Biomol. Chem. 2012, Advance Article (doi: 10.1039/C2OB25459J)

27) Frédéric Frébault and Nuno Maulide*,
Total Synthesis and Structural Revision of the Piperarborenines: When Photochemistry Meets C-H Activation.
Angew. Chem. 2012, 124, 2869-2871
Angew. Chem. Intern. Ed. 201251, 2815-2817

26) Igor Dias Jurberg, Bo Peng, Eckhard Wöstefeld, Maximilian Wasserloos and Nuno Maulide*
Intramolecular Redox-Triggered C-H Functionalisation.
Angew. Chem. Int. Ed. 2012, 51, 1950-1953
Angew. Chem. 2012, 124, 1986-1989
(Selected as a Hot paper by the Editorial Team)

25) Xueliang Huang, Sebastian Klimczyk and Nuno Maulide*
Charge-Accelerated Sulfonium [3,3]-Sigmatropic Rearrangements.
Synthesis 2012, 175-183.

2011

24) Marco Luparia, Maria Teresa Oliveira, Davide Audisio, Frédéric Frébault and Nuno Maulide*
Catalytic Asymmetric Diastereodivergent Deracemisation.
Angew. Chem. Intern. Ed. 2011, 50, 12631-12635.
Angew. Chem. 2011, 123, 12840-12844.

Highlighted in: Nature Chemistry 2012, 4, 4.
Highlighted in: Synfacts 2012, 3, 298.

23) Xueliang Huang and Nuno Maulide*:
Metal-Free Arylation of Carbonyl Compounds with Sulfoxides.
J. Am. Chem. Soc. 2011, 133, 8510-8513.

22) Claire Madelaine, Viviana Valerio and Nuno Maulide*:
Keteniminium Salts: More Than the Nitrogen Analogues of Ketenes.
Chem. Asian J. 2011, 6, 2224-2239.

21) Viviana Valerio, Claire Madelaine and Nuno Maulide*:
Steering Reaction Pathways: From Benzyl Claisen Rearrangements to Powerful Ionic Shifts.
Chem. Eur. J. 2011, 17, 4742-4745.

20) Marco Luparia, Davide Audisio and Nuno Maulide*:
Palladium-Catalysed Synthesis of Stereodefined Cyclobutenes.
Synlett 2011, 735-740.

2010

19) Frédéric Frébault, Maria Teresa Oliveira, Eckhard Wöstefeld and Nuno Maulide*:
A Concise Acceass to 3-Substituted 2-Pyrones.
J. Org. Chem. 2010, 75, 7962-7965.

18) Nuno Maulide*:
A Feast and a Reflection on Organocatalysis - Notes from the ISOµ in Mülheim.
Eur. J. Org. Chem. 2010, 34, 6491-6493 Conference Report.

17) Xueliang Huang, Richard Goddard and Nuno Maulide*:
A Direct Ylide Transfer to Carbonyl Derivatives and Heteroaromatic Compounds.
Angew. Chem. Int. Ed. 2010, 49, 8979-8983.
Direkter Ylidtransfer auf Carbonylverbindungen und Heteroarene.
Angew. Chem. 2010, 122, 9163-9167.

16) Sónia Barroso, Ana M. Abreu, Ana C. Araújo, Ana M. Coelho, Nuno Maulide* and Ana M. Martins*:
Three-component Mannich couplings en route to substituted aminophenol and benzoxazine derivatives.
Synlett 2010, 16, 2425-2428.

15) Frédéric Frebault, Marco Luparia, Maria Teresa Oliveira, Richard Goddard and Nuno Maulide*:
A Versatile and Stereoselective Synthesis of Functionalized Cyclobutenes.
Angew. Chem. Int. Ed. 2010, 49, 5672-5676.
Eine vielseitige und stereoselektive Synthese funktionalisierter Cyclobutene.
Angew. Chem. 2010, 122, 5807-5811.

14) Claire Madelaine, Viviana Valerio and Nuno Maulide*:
Unexpected electrophilic rearrangements of amides: A stereoselective entry to challengingly substituted lactones.
Angew. Chem. Int. Ed. 2010, 49, 1583-1586.
Unerwartete nucleophile Umlagerung von Amiden: Ein stereoselektiver Zugang zu anspruchsvoll substituierten Lactonen.
Angew. Chem. 2010, 122, 1628-1631.

2009

13) Barry M. Trost*, Nuno Maulide and Michael T. Rudd:
Ruthenium-catalyzed cross-coupling of tertiary propargyl alcohols with ω-alkynenitriles: A regio- and stereoselective surrogate for an aldol condensation.
J. Am. Chem. Soc. 2009, 131, 420-421.

2008

12) Barry M. Trost*, Jia Xie and Nuno Maulide:
Stereoselective, dual-mode ruthenium-catalyzed ring-expansion of alkynylcyclopropanols.
J. Am. Chem. Soc. 2008, 130, 17258-17259.

11) Barry M. Trost*, Nuno Maulide and Robert C. Livingston:
A Ruthenium-catalysed, atom-economical synthesis of nitrogen heterocycles.
J. Am. Chem. Soc. 2008130, 16503-16503.

10) Rui F. Munhá, Luís G. Alves, Nuno Maulide, M. Teresa Duarte, István E. Markó, Michael D. Fryzuk and Ana M. Martins*:
trans-Disubstituted diamido/diamine cyclam zirconium complexes.
Inorg. Chem. Comm. 2008, 11, 1174-1178.

2004-2007

9) Nuno Maulide, Jean-Christophe Vanherck, Arnaud Gautier and István E. Markó*:
Mild and Neutral Deprotections Catalyzed by Cerium(IV) Ammonium Nitrate.
Acc. Chem. Res. 2007, 40, 381-392.

8) Nuno Maulide and István E. Markó*:
Synthesis and ring-expansions of functionalised spiroyclobutanones.
Org. Lett. 2007, 9, 3757-3760.

7) Jyh-Hsiung Liao, Nuno Maulide, Benoît Augustyns and István E. Markó*:
Tandem radical rearrangement / Pd-catalysed translocation of bicyclo[2.2.2]lactones. An efficient access to the oxa-triquinane core structure.
Org. Biomol. Chem. 2006, 4, 1464-1467.

6) Nuno Maulide and István E. Markó*:
2-(Trimethylsilyloxy)furan as a Dianion Equivalent: a Two-Step Synthesis of Functionalised Spirocyclic Butenolides.
Org. Lett. 2006, 8, 3705-3707.

5) Nuno Maulide and István E. Markó*:
Stereoselective synthesis of bicyclic lactones by annelation with functionalised orthoesters.
Chem. Comm. 2006, 11, 1200-1202 (Hot article).

4) Nuno Maulide and István E. Markó*:
Cerium(IV) Ammonium Nitrate (CAN) catalyzed highly chemoselective deprotection of ketals and THP ethers in the presence of enol triflates.
Synlett 2005, 14, 2195-2198.

3) Benoît Augustyns, Nuno Maulide and István E. Markó*:
Skeletal rearrangements of bicyclo[2.2.2]lactones: a short and efficient route towards Corey’s Lactone.
Tetrahedron Lett. 2005, 46, 3895-3899.

2) Nicolas Heureux, Mélanie Marchant, Nuno Maulide, Guillaume Berthon-Gelloz, Christophe Hermans, Sébastien Hermant, Eleonóra Kiss, Bernard Leroy, Pierre Wasnaire and István E. Markó*:
Preparation and applications of a novel bis(tributylstannyl)cyclopropane: a synthetic equivalent of a cyclopropane-1,2-dianion.
Tetrahedron Lett. 2005, 46, 79-83.

1) Nuno Maulide, Jean-Christophe Vanherck and István E. Markó*:
Connective synthesis of spirovetivanes: Total Synthesis of (±)-Agarospirol, (±)-Hinesol and (±)-α-Vetispirene.
Eur. J. Org. Chem. 2004, 19, 3962-3967.

 

Research Topics

Stereoselective synthesis and catalysis
Stereoselective synthesis and catalysis

Stereoselective synthesis and catalysis

In recent years, the importance of rapidly increasing molecular complexity through highly efficient chemical transformations in synthesis has become a reality. Current research interests in group are broad in nature and span novel pericyclic reactions, catalytic asymmetric synthesis of small rings and new ylide transfer methodologies. We are also interested in stereo- and chemoselective manipulation of non-activated C-H bonds, particularly those borne by sp3-carbon centers.

 

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