Dr. Nuno Maulide

Since 2009

Max-Planck Research Group Leader (W2/Associate Professor without tenure) at the Max-Planck Institut für Kohlenforschung

2007-2008

Postdoctoral studies at Stanford University, USA (Prof. Barry M. Trost), on ruthenium-catalysed bond-forming reactions.

2007

Ph.D. from Université catholique de Louvain, Louvain-la-Neuve, Belgium (Prof. István E. Markó) on new bifunctional reagents for the synthesis of cyclic compounds.

2004

Masters Degree from Ecole Polytechnique (Paris, France) and Université catholique de Louvain (Louvain-la-Neuve, Belgium).

2003

Chemistry Degree from the Instituto Superior Técnico, Lisbon (6-month internship at Clariant AG, Basel).

1979

Born in Lisbon, Portugal

2013

Heinz-Maier-Leibnitz Prize

2012

Bayer Early Excellence in Science Award

2012

ADUC Jahrespreis für Habilitanden (2011/2012)

2011

European Research Council (ERC) Starting Grant

2010

Thieme Journal Award

2009

Member of the Global Young Faculty

2009

Appointed Group Leader by the Max-Planck Society

2007

Post-Doctoral Fellowship from the Fundação para a Ciência e Tecnologia (FCT)

2007

Laureate of the DSM Awards in Science & Technology 2007

2007

Roche Award

2006

Best oral communication at the Frühjahrssymposium 2006

2005

Best oral communication at the YoungChem 2005

2005

Aspirant FNRS at the Université catholique de Louvain

2005

Lhoist R&D Prize

2003

Ph.D. Scolarship from the Fonds pour la Recherche dans l'Industrie et l'Agriculture (FRIA)

2002

IAESTE scolarship for a 6-month industrial internship (Clariant AG, Basel)

2002

Merit scolarship for excellence in Chemistry studies

2001

Merit scolarship for excellence in Chemistry studies

2000

Merit scolarship for excellence in Chemistry studies

2013, Summer semester, Ruhr-Universität Bochum:
"Strategies and Tactics in Organic Synthesis"

This lecture aimed at discussing how a complex molecule can be approached from a synthetic point of view. In order to do so, selected syntheses were analysed and commented on. Emphasis was placed on retrosynthetic disconnections and their reduction to practice, on maximisation of synthetic efficiency and on the discussion of new methods in Organic Chemistry. Students were encouraged to think creatively and suggest "out-of-the-box" approaches whenever possible.

2012, Summer semester, Ruhr-Universität Bochum:
"Strategies and Tactics in Organic Synthesis"

This lecture aimed at discussing how a complex molecule can be approached from a synthetic point of view. In order to do so, selected syntheses were analysed and commented on. Emphasis was placed on retrosynthetic disconnections and their reduction to practice, on maximisation of synthetic efficiency and on the discussion of new methods in Organic Chemistry. Students were encouraged to think creatively and suggest "out-of-the-box" approaches whenever possible.

2011, Summer semester, Ruhr-Universität Bochum:
"Strategies and Tactics in Organic Synthesis"

This lecture aimed at discussing how a complex molecule can be approached from a synthetic point of view. In order to do so, selected syntheses were analysed and commented on. Emphasis was placed on retrosynthetic disconnections and their reduction to practice, on maximisation of synthetic efficiency and on the discussion of new methods in Organic Chemistry. Students were encouraged to think creatively and suggest "out-of-the-box" approaches whenever possible.

 

2013

41) Saad Shabaan, Bo Peng and Nuno Maulide*
Base-Promoted Internal Redox Cyclization Reactions
Synlett, 2013, accepted

40) Xueliang Huang, Mahendra Patil, Christophe Farès, Walter Thiel and Nuno Maulide*
Sulfur(IV)-Mediated Transformations: From Ylide Transfer to Metal-Free Arylation of Carbonyl Compounds
J. Am. Chem. Soc., 2013, 135 (19), 7312-7323

39) Supaporn Niyomchon, Davide Audisio, Marco Luparia and Nuno Maulide*
Regio- and Stereoselective Cyclobutene Allylations”
Org. Lett., 2013, 15 (9), 2318-2321

38) Caroline Souris, Frédéric Frébault, Davide Audisio, Christophe Farès and Nuno Maulide*
Direct Domino Synthesis of Azidodienoic Acids: Potential Linker Units
Synlett 2013, Early View (doi: 10.1055/s-0033-1338452)

37) Davide Audisio, Gopinadhanpillai Gopakumar, Lan-Gui Xie, Luís G. Alves, Cornelia Wirtz, Ana M. Martins, Walter Thiel, Christophe Farès and Nuno Maulide*Palladium-Catalyzed Allylic Substitution at Four Membered Cyclic Systems: Formation of (eta)1-allyl Complexes and Electrocyclic Ring Opening
Angew. Chem. Int. Ed. 2013, Early View (doi:10.1002/anie.201301034)
Palladium-katalysierte allylische Substitution an viergliedrigen Ringen: Bildung von η1-Allylkomplexen und elektrocyclische Ringöffnung†
Angew. Chem. 2013, Early View (doi:10.1002/ange.201301034)

36) Caroline Souris, Frédéric Frébault, Davide Audisio, Christophe Farès, Richard Goddard and Nuno Maulide*
An Atom-Economical and Stereoselective Domino Synthesis of Functionalised Dienes
Chem. Eur. J. 2013, 19 (21), 6566-6570

35) Xueliang Huang, Sebastian Klimczyk, Luís F. Veiros and Nuno Maulide*
Stereoselective Intramolecular Cyclopropanation through Catalytic Olefin Activation
Chem. Sci., 2013, 4 , 1105 - 1110

34) Viviana Valerio, Desislava Petkova, Claire Madelaine and Nuno Maulide*
Direct Room-Temperature Lactonisation of Alcohols and Ethers onto Amides: an “Amide Strategy” for Synthesis
Chem. Eur. J. 2013, 19, 2606-2610

33) Maria Teresa Oliveira, Davide Audisio, Supaporn Niyomchon and Nuno Maulide*
Diastereodivergent Processes in Palladium-Catalyzed Allylic Alkylation
ChemCatChem 2013, Early View (doi:10.1002/cctc.201200644)

32) Xueliang Huang, Richard Goddard and Nuno Maulide*
Facile carbon-sulfur bond cleavage in diarylsulfonium ylides: a catalytic sulfur-to-silicon group transfer
Chem. Commun. 2013, 49, 4292-4294
(Invited contribution for the Emerging Investigators Issue)

2012

31) Bo Peng, Daniel O’Donovan, Igor D. Jurberg and Nuno Maulide*
Dual Nucleophilic/Electrophilic Capture of In-Situ Generated Iminium Ethers: Towards the Synthesis of Functionalized Amide Building Blocks
Chem. Eur. J. 2012, 18, 16292-16296

30) Xueliang Huang, Bo Peng, Marco Luparia, Luis Gomes, Luís F. Veiros and Nuno Maulide*,
Gold-Catalysed Synthesis of Furans and Furanones from Sulfur Ylides.
Angew. Chem. Int. Ed. 2012, 51, 8886-8890
Gold-katalysierte Synthese von Furanen und Furanonen aus Schwefel-Yliden
Angew. Chem. 2012, 124, 9016-9020

29) Davide Audisio, Marco Luparia, Maria Teresa Oliveira, Frédéric Frébault, Dina Klütt and Nuno Maulide*,
A Diastereodivergent De-epimerisation in Catalytic Asymmetric Allylic Alkylation.
Angew. Chem. Int. Ed. 2012, 51, 7314-7317
Eine diastereodivergente De-Epimerisierung in einer katalytischen asymmetrischen allylischen Alkylierung
Angew. Chem. 2012, 124, 7426-7429
(Selected as Hot paper by the Editorial Team)

28) Sebastian Klimczyk, Xueliang Huang, Christophe Farès and Nuno Maulide*,
Sulfoxide-mediated Umpolung of alkali halide salts
Org. Biomol. Chem. 2012, 10 (22), 4327 - 4329
(Selected as Cover Picture by the Editorial Team)

27) Frédéric Frébault and Nuno Maulide*,
Total Synthesis and Structural Revision of the Piperarborenines: When Photochemistry Meets C-H Activation.
Angew. Chem. Int. Ed. 2012,  51, 2815-2817
Totalsynthese und Strukturrevision der Piperarborenine: Photochemie trifft auf C-H-Aktivierung
Angew. Chem. 2012, 124, 2869-2871

26) Igor Dias Jurberg, Bo Peng, Eckhard Wöstefeld, Maximilian Wasserloos and Nuno Maulide*
Intramolecular Redox-Triggered C-H Functionalisation.
Angew. Chem. Int. Ed. 2012, 51, 1950-1953
C-H-Funktionalisierung durch eine intramolekulare Redox-Strategie
Angew. Chem. 2012, 124, 1986-1989
(Selected as a Hot paper by the Editorial Team)

25) Xueliang Huang, Sebastian Klimczyk and Nuno Maulide*
Charge-Accelerated Sulfonium [3,3]-Sigmatropic Rearrangements.
Synthesis 2012, 175-183.

2011

24) Marco Luparia, Maria Teresa Oliveira, Davide Audisio, Frédéric Frébault and Nuno Maulide*
Catalytic Asymmetric Diastereodivergent Deracemisation.
Angew. Chem. Int. Ed. 2011, 50, 12631-12635.
Katalytische asymmetrische diastereodivergente Deracemisierung
Angew. Chem. 2011, 123, 12840-12844.
Highlighted in: Nature Chemistry 2012, 4, 4.
Highlighted in: Synfacts 2012, 3, 298.

23) Xueliang Huang and Nuno Maulide*:
Metal-Free Arylation of Carbonyl Compounds with Sulfoxides.
J. Am. Chem. Soc. 2011, 133, 8510-8513.

22) Claire Madelaine, Viviana Valerio and Nuno Maulide*:
Keteniminium Salts: More Than the Nitrogen Analogues of Ketenes.
Chem. Asian J. 2011, 6, 2224-2239.

21) Viviana Valerio, Claire Madelaine and Nuno Maulide*:
Steering Reaction Pathways: From Benzyl Claisen Rearrangements to Powerful Ionic Shifts.
Chem. Eur. J. 2011, 17, 4742-4745.

20) Marco Luparia, Davide Audisio and Nuno Maulide*:
Palladium-Catalysed Synthesis of Stereodefined Cyclobutenes.
Synlett 2011, 735-740.

2010

19) Frédéric Frébault, Maria Teresa Oliveira, Eckhard Wöstefeld and Nuno Maulide*:
A Concise Acceass to 3-Substituted 2-Pyrones.
J. Org. Chem. 2010, 75, 7962-7965.

18) Nuno Maulide*:
A Feast and a Reflection on Organocatalysis - Notes from the ISOµ in Mülheim.
Eur. J. Org. Chem. 2010, 34, 6491-6493 Conference Report.

17) Xueliang Huang, Richard Goddard and Nuno Maulide*:
A Direct Ylide Transfer to Carbonyl Derivatives and Heteroaromatic Compounds.
Angew. Chem. Int. Ed. 2010, 49, 8979-8983.
Direkter Ylidtransfer auf Carbonylverbindungen und Heteroarene.
Angew. Chem. 2010, 122, 9163-9167.

16) Sónia Barroso, Ana M. Abreu, Ana C. Araújo, Ana M. Coelho, Nuno Maulide* and Ana M. Martins*:
Three-component Mannich couplings en route to substituted aminophenol and benzoxazine derivatives.
Synlett 2010, 16, 2425-2428.

15) Frédéric Frebault, Marco Luparia, Maria Teresa Oliveira, Richard Goddard and Nuno Maulide*:
A Versatile and Stereoselective Synthesis of Functionalized Cyclobutenes.
Angew. Chem. Int. Ed. 2010, 49, 5672-5676.
Eine vielseitige und stereoselektive Synthese funktionalisierter Cyclobutene.
Angew. Chem. 2010, 122, 5807-5811.

14) Claire Madelaine, Viviana Valerio and Nuno Maulide*:
Unexpected electrophilic rearrangements of amides: A stereoselective entry to challengingly substituted lactones.
Angew. Chem. Int. Ed. 2010, 49, 1583-1586.
Unerwartete nucleophile Umlagerung von Amiden: Ein stereoselektiver Zugang zu anspruchsvoll substituierten Lactonen.
Angew. Chem. 2010, 122, 1628-1631.

2009

13) Barry M. Trost*, Nuno Maulide and Michael T. Rudd:
Ruthenium-catalyzed cross-coupling of tertiary propargyl alcohols with ω-alkynenitriles: A regio- and stereoselective surrogate for an aldol condensation.
J. Am. Chem. Soc. 2009, 131, 420-421.

2008

12) Barry M. Trost*, Jia Xie and Nuno Maulide:
Stereoselective, dual-mode ruthenium-catalyzed ring-expansion of alkynylcyclopropanols.
J. Am. Chem. Soc. 2008, 130, 17258-17259.

11) Barry M. Trost*, Nuno Maulide and Robert C. Livingston:
A Ruthenium-catalysed, atom-economical synthesis of nitrogen heterocycles.
J. Am. Chem. Soc. 2008130, 16503-16503.

10) Rui F. Munhá, Luís G. Alves, Nuno Maulide, M. Teresa Duarte, István E. Markó, Michael D. Fryzuk and Ana M. Martins*:
trans-Disubstituted diamido/diamine cyclam zirconium complexes.
Inorg. Chem. Comm. 2008, 11, 1174-1178.

2004-2007

9) Nuno Maulide, Jean-Christophe Vanherck, Arnaud Gautier and István E. Markó*:
Mild and Neutral Deprotections Catalyzed by Cerium(IV) Ammonium Nitrate.
Acc. Chem. Res. 2007, 40, 381-392.

8) Nuno Maulide and István E. Markó*:
Synthesis and ring-expansions of functionalised spiroyclobutanones.
Org. Lett. 2007, 9, 3757-3760.

7) Jyh-Hsiung Liao, Nuno Maulide, Benoît Augustyns and István E. Markó*:
Tandem radical rearrangement / Pd-catalysed translocation of bicyclo[2.2.2]lactones. An efficient access to the oxa-triquinane core structure.
Org. Biomol. Chem. 2006, 4, 1464-1467.

6) Nuno Maulide and István E. Markó*:
2-(Trimethylsilyloxy)furan as a Dianion Equivalent: a Two-Step Synthesis of Functionalised Spirocyclic Butenolides.
Org. Lett. 2006, 8, 3705-3707.

5) Nuno Maulide and István E. Markó*:
Stereoselective synthesis of bicyclic lactones by annelation with functionalised orthoesters.
Chem. Comm. 2006, 11, 1200-1202 (Hot article).

4) Nuno Maulide and István E. Markó*:
Cerium(IV) Ammonium Nitrate (CAN) catalyzed highly chemoselective deprotection of ketals and THP ethers in the presence of enol triflates.
Synlett 2005, 14, 2195-2198.

3) Benoît Augustyns, Nuno Maulide and István E. Markó*:
Skeletal rearrangements of bicyclo[2.2.2]lactones: a short and efficient route towards Corey’s Lactone.
Tetrahedron Lett. 2005, 46, 3895-3899.

2) Nicolas Heureux, Mélanie Marchant, Nuno Maulide, Guillaume Berthon-Gelloz, Christophe Hermans, Sébastien Hermant, Eleonóra Kiss, Bernard Leroy, Pierre Wasnaire and István E. Markó*:
Preparation and applications of a novel bis(tributylstannyl)cyclopropane: a synthetic equivalent of a cyclopropane-1,2-dianion.
Tetrahedron Lett. 2005, 46, 79-83.

1) Nuno Maulide, Jean-Christophe Vanherck and István E. Markó*:
Connective synthesis of spirovetivanes: Total Synthesis of (±)-Agarospirol, (±)-Hinesol and (±)-α-Vetispirene.
Eur. J. Org. Chem. 2004, 19, 3962-3967.

• Download Complete List of Publications (PDF)

2013:
- Bayer Medicinal Chemistry Berlin, 8 May 2013, Berlin, D
- Albert-Ludwigs University Freiburg, 6 May 2013, Freiburg, D
- Novartis Chemistry Basel, 15 January 2014, Basel, CH (upcoming)
- 15th Asian Chemistry Congress, 19-23 August 2013, Singapore (Invited Speaker, upcoming)
- Johann-Goethe-Universität Frankfurt, 28 June 2013, Frankfurt, D (upcoming)
- Kaiserslautern University, 13 June 2013, Kaiserslautern, D (upcoming)
- FSU Jena, 5 June 2013, Jena, D (upcoming)
- ETH Zurich, 22 April 2013, Zurich, CH
- Université catholique de Louvain, 19 April 2013, Louvain-la-Neuve, B
- Bayer Early Excellence in Science Award Ceremony, 15 April 2013, Muelheim an der Ruhr, D
- Chemiedozententagung 2013, 13 March 2013, Berlin, D
- Janssen Pharmaceutica, 28 March 2013, Beerse, B
- Institute Seminar of the Max-Planck-Institut für Kohlenforschung, 7 February 2013, Muelheim an der Ruhr, D
- Universität Regensburg, 30 January 2013, Regensburg, D

2012:
- Ecole Polytechnique Fédérale de Lausanne (EPFL), 28 November 2012, Lausanne, CH
- Institut de Chimie des Substances Naturelles (ICSN), 8 November 2012, Gif-sur-Yvette, F
- Sanofi-Aventis, 5 October 2012, Frankfurt, D
- International Conference “Catalysis in Organic Synthesis” (ICCOS-2012), 15-20 September 2012, Moscow, RU (Invited Speaker)
- European Young Chemist Award Final Round, 29 August 2012, Prague, CZE
- EuCheMS 4th Chemistry Congress, 26-30 August 2012, Prague, CZE
- EuCheMS Young Investigators Workshop, 23-25 August 2012, Vienna, A
- 7th Asian-European Symposium, 22-25 July 2012, Tarragona, E, Keynote
- Boston University, 29 June 2012, Boston, USA
- Universität Hannover, 19 June 2012, Hannover, D
- Rencontres de Chimie Organique VII, 14-16 June 2012, Marseille, F (Keynote)
- Ruhr-Universität Bochum (GDCh Lecture), 10 May 2012, Bochum, D
- Technische Universität Darmstadt, 23 April 2012, Darmstadt, D
- ‘Monheimer Kolloquium’, Bayer CropScience, 30 March 2012, Monheim, D
- Chemiedozententagung 2012, 5-6 March 2012, Freiburg, DE
- Université Pierre et Marie Curie, 13 February 2012, Paris, FR
- Sociedade Portuguesa de Química, 9 February 2012, Lissabon, PT

2011:
- Phillips-Universität Marburg, 6 February 2011, Marburg, DE.
- Rijksuniversiteit Groningen, 8 December 2011, Groningen, NL.
- Humboldt-Universität Berlin, 23 November 2011, Berlin, DE.
- Faculdade de Farmácia de Lisboa, 11 November 2011, Lissabon, PT.
- Swiss Chemical Society Fall Meeting, 9 September 2011, Lausanne, CH.
- GDCh Wissenschaftsforum, 4-7 September 2011, Bremen, DE.
- ESF-COST High-Level Conference “Natural Products Chemistry, Biology and
   Medicine IV”, 28 Aug.-2 Sep. 2011, Acquafredda di Maratea, IT.
- European Symposium on Organic Chemistry (ESOC), 10-15 July 2011, Crete, GR.
- 22nd Encontro Nacional de Quimica, 3-6 July 2011, Braga, PT.
- Bayer Healthcare, 21 June 2011, Wuppertal, DE.
- Ludwigs-Maximilian-Universität München, 16 May 2011, Munich, DE.
- Chemiedozententagung 2011, 14-15 March 2011, Mainz, DE.
- Universität zu Köln, 14 January 2011, Cologne, DE (invited lecture).

2010:
- Ruprechts-Karl-Universität Heidelberg, 22 July 2010, Heidelberg, DE (invited lecture).

2009:
- Ruhr-Universität Bochum, 16 July 2009, Bochum, DE (invited lecture).
- 8th ENQO, 1-3 July 2009, Aveiro, PT (invited lecture).

2008:
- Max-Planck Institut für Kohlenforschung, 2 December 2008, Mülheim, DE (invited lecture).
- Instituto Superior Técnico, 24 November 2008, Lisbon, PT (invited lecture).
- 1st PyCHEM, 15-17 October 2008, Lisbon, PT.
- Syngenta AG, 2 April 2008, Stein, CH (invited lecture).
- SNWG Symposium of the Max-Planck Society, 7-9 February 2008, Berlin, DE.

2007:
- Ph.D. Final Examination, 20 July 2007, Louvain-la-Neuve, BE.
- DSM Awards in Science & Technology 2007, 3-5 June 2007, La Hulpe, BE.
- Roche Symposium for Leading Scientists of the Next Decade, 14-16 March 2007, Basel, CH.
- Journées de Rencontre des Jeunes Chimistes de la SRC, 8-9 March 2007, Herbeumont, BE.

2006:
- 10th Sigma-Aldrich Organic Synthesis Meeting, 7 December 2006, Spa, BE.
- 10th Ph.D. Students’ Day, 19 May 2006, Louvain-la-Neuve, BE.
- Ecole Doctorale de Chimie, 29 March 2006, Louvain-la-Neuve, BE (invited lecture).
- Frühjahrssymposium 2006, 16-18 March 2006, Konstanz, DE.

2005:
- SAJEC 2005, 17-19 October 2005, Lille, FR.
- European Young Chemists’ Congress (YoungChem), 12-16 October 2005, Rydzyna, PL.
- Journées de Rencontre des Jeunes Chimistes de la SRC, 22-25 March 2005, Cul-des-S., BE.

 2013, Summer semester, Ruhr-Universität Bochum:
"Strategies and Tactics in Organic Synthesis"

This lecture aimed at discussing how a complex molecule can be approached from a synthetic point of view. In order to do so, selected syntheses were analysed and commented on. Emphasis was placed on retrosynthetic disconnections and their reduction to practice, on maximisation of synthetic efficiency and on the discussion of new methods in Organic Chemistry. Students were encouraged to think creatively and suggest "out-of-the-box" approaches whenever possible.

2012, Summer semester, Ruhr-Universität Bochum:
"Strategies and Tactics in Organic Synthesis"

This lecture aimed at discussing how a complex molecule can be approached from a synthetic point of view. In order to do so, selected syntheses were analysed and commented on. Emphasis was placed on retrosynthetic disconnections and their reduction to practice, on maximisation of synthetic efficiency and on the discussion of new methods in Organic Chemistry. Students were encouraged to think creatively and suggest "out-of-the-box" approaches whenever possible.

2011, Summer semester, Ruhr-Universität Bochum:
"Strategies and Tactics in Organic Synthesis"

This lecture aimed at discussing how a complex molecule can be approached from a synthetic point of view. In order to do so, selected syntheses were analysed and commented on. Emphasis was placed on retrosynthetic disconnections and their reduction to practice, on maximisation of synthetic efficiency and on the discussion of new methods in Organic Chemistry. Students were encouraged to think creatively and suggest "out-of-the-box" approaches whenever possible.

• May, 2013
  Dr. Nuno Maulide receives the Heinz-Maier-Leibnitz-Prize! Congratulations!
  DFG Press release / Winner profile
  Informationsdienst Ruhr (German website)
  
  Dr. Maulide is also mentioned in a popular portuguese talk show (approx. 9:15 min):
  TVI 2013-05-05
   
• April, 2013
  The  Award Ceremony for the Bayer Early Excellence in Science Award takes place at the MPI. Dr. Maulide seizes the opportunity to demonstrate his ability at the piano.
  
  Even the portuguese press shows interest:
  Boas Notícias
  Potenciar Portugal
  Rádio Sim
   

• December 2012
  Dr. Nuno Maulide receives the “Bayer Early Excellence in Science Award”. Congratulations! 
   

• October 2012
  Sebastian Klimczyk receives the 2nd prize for Best Oral Communication and Viviana Valerio the prize for Best Poster at the 10. YoungChem in Gdansk (Poland). Congratulations!
   
• September 2012
  Desislava Petkova receives the prize for Best Oral Communication at the JCF-Ruhr meeting "Junges Chemie Symposium"  in Dortmund. Congratulations!
   

• March, 2012
  Maria Teresa Oliveira got the 1st Oral Presentation Award in the 14th JCF-Frühjahrssymposium in Rostock. Congratulations!
  
  Dr. Nuno Maulide gives a short interview to Portuguese radio. You can listen to it here (in Portugese):
  http://tv2.rtp.pt/multimediahtml/progAudio.php?prog=3988