Our group performs fundamental research in the areas
Transition metals under focus are Ni, Pd, and Pt, which often are used in combination with main group metals compounds (Li, Mg, Al, Ge, Sn), and Co–Ir.
While plastic crystals (dynamically-orientationally disordered mesogens) are so far rare in organometallic chemistry, we discovered that formally five-coordinate ionic Ni(II) complexes [(π-allyl)NiL3]Y and neutral M(I) complexes (π-allyl)ML3 (M = Co, Rh, Ir) with L = PMe3, P(OMe)3, and other ligands undergo a phase transition from the ordered to a plastic phase. The plastic properties arise from mobility of the π-allyl group in the solid-state. For the ionic Ni compounds, besides motion of the anions Y, the cations appear to tumble on their site in the lattice, whereas the neutral M(I) complexes rotate about an axis. For recrystallization, some compounds require partial ordering in a glassy-crystalline state.
Among the most prominent anti-cancer drugs are cisplatin, carboplatin, and oxaliplatin. Therapy with these drugs is frequently associated with a bunch of serious side-effects, and inherent or acquired platinum resistance is also an obstacle. In the search for complexes which may overcome these problems we are studying Pt complexes of the parent bispidine (3,7-diazabicyclo[3.3.1]nonane, C7H14N2) (e.g., (C7H14N2)PtCl2 x 3 H2O) and its derivatives.
Our group has a long history in studying complexes of Ni, Pd, Pt, and Cu with acyclic and cyclic alkene and alkyne ligands, in particular those comprising the functional groups in 1,6- or 1,6,11-sequence. At present, in cooperation with a Spanish group (A. Roglans, University of Girona) the coordination of macrocyclic mixed polyene-yne ligands at Ni(0) is studied.
Dr. Cui, Huiling
Forero Cortés, Paola Andrea
Dr. Mitra, Raja
Prof. Dr. Pörschke (im Ruhestand), Klaus-Richard