The transition of chemical production to processes that are environmentally benign and sustainable is a big challenge for our society and for chemical research. Homogeneous catalysis can make a substantial contribution by developing processes that convert simple substrates into valuable products without using synthetic reagents in stoichiometric amounts or large amounts of energy. The development of such processes is the prime goal of our research group.
2013 to date
Lecture and seminar "Fortgeschrittene Organische Chemie" for the bachelor degree course, University of Cologne
2008 to date
Lecture, seminar and pracitcal course in organic chemistry "Kalorimetrie und Kinetik", University of Cologne
Our first two mechanistic studies on the Cu-catalyzed oxidative coupling with N-phenyl tetrahydroisoquinolines (J. Am. Chem. Soc. 2011 und 2012) have been cited over 100 times each.
A short review on oxidative coupling reactions, our research focus, appears in the journal G.I.T. Labor-Fachzeitschrift (in German): „Chemische Synthese: Funktionalisierung von C-H-Bindungen durch oxidative Kupplung unter Verwendung von Sauerstoff“, see: http://www.git-labor.de/forschung/chemie-physik/chemische-synthese-funktionalisierung-von-c-h-bindungen-durch-oxidative-kupp
Naeem finished his PhD at the University of Cologne with magna cum laude (very good), congratulations!
Anda and Sophia from Greece join the group for two months, funded by the ERASMUS-programme – welcome!
A kinetic study on the reaction mechanism of the Cu-catalyzed oxidative coupling reaction with amines (N-phenyltetrahydroisoquinoline) appears online in J. Org. Chem. (J. Org. Chem., 2014, 79 (24), pp 12033–12040).
Bertrand and Martin present research results at the EUCHEM Conference on Organic Free Radicals in Prague (http://www.uochb.cz/web/structure/1259.html).
Bertrand finishes his PhD at the University of Cologne with grade 0,7 (magna cum laude, very good).
Our paper on the acid catalyzed oxidative addition of ketones to olefins (publicaton 33) is highlighted in SYNFACTS (Synfacts 2014, 10(7), 0758).
The activation of C-H bonds is an important goal in chemical research. The direct substitution of hydrogen in C-H bonds by a desired fragment creates interesting synthetic alternatives to the more common multi-step approach of first introducing reactive functional groups. Instead, only one step is needed and very simple substrates can be used, as C-H bonds are ubiquitous in organic compounds. Oxidative coupling reactions can achieve such transformations by utilizing an oxidant and a catalyst.
In our group, we focus on the development of such reactions under mild and sustainable conditions, i.e., preferably by using elemental oxygen or simple peroxides as oxidant.
We are also developing other methods for direct and atom economic organic syntheses, for example to access starting materials for our projects or to apply strategies that were inspired by our mechanistic studies.
We are highly interested in investigating the mechanism of organic reactions. We study reactions developed in our own group, but also others and we are always interested in collaborations with other research groups. We use a variety of techniques, including synthetic, spectroscopic and kinetic studies (e.g., see J. Am. Chem. Soc. 2012, 134, 5317). To obtain kinetic data, we use NMR spectroscopy or reaction calorimetry. We like to evaluate the data by Donna Blackmond’s method of Reaction Progress Kinetic Analysis (e.g., see J. Org. Chem. 2014, 79, 12033). In collaboration with other scientists, we combine experimental with theoretical mechanistic studies (e.g., see Chem. Eur. J. 2015).
Iosub, Andrei V.
Dr. Jones, Kevin Mark
PD Dr. Klußmann, Martin
Dr. Schweitzer-Chaput, Bertrand
Dr. Uemiya, Nobuhito